Abstract
Transient osmotic disruption of the BBB has been advocated by Neuwelt et al. [3] as a vehicle for increased drug delivery into the brain for treatment of central nervous system (CNS) malignancies. However, a number of drugs administered in this manner have been shown to be neurotoxic [4]. This study was designed to investigate the effects of hyperosmolar solutions on the endothelium of the major extracranial and intracranial arteries and to contrast this with the effects on the cerebral capillary endothelium. A potential risk of injury to the vessels exists if antineoplastic drugs are able to penetrate the vessel wall following the administration of mannitol.
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© 1985 Springer-Verlag Berlin Heidelberg
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Godersky, J.C., Sasaki, T., Kassell, N.F. (1985). Differences in Response of Large-Vessel Endothelium and Capillary Endothelium Following Intracarotid Mannitol. In: Inaba, Y., Klatzo, I., Spatz, M. (eds) Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70696-7_19
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DOI: https://doi.org/10.1007/978-3-642-70696-7_19
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