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Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?

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Images of Biologically Active Structures in the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 119))

Abstract

The specific binding and physiological modulation of physiological membrane receptors by anti-idiotypic (anti-Id) antibodies has now been described in several systems (reviewed in Strosberg and Schreiber 1984). Two types of explanations have been given for these unexpected interactions. The anti-Id antibody either acts as an internal image of the ligand recognized by both the physiological receptor and the anti-ligand antibody (Jerne 1974, 1984) or, alternatively, there is recognition, by the anti-Id antibodies, of structural homologies shared by the Id-bearing antiligand antibodies and the receptor (Strosberg 1984).

This work was supported by grants from the Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale (contrat “Recherche Externe”), Association pour le Développement de la Recherche sur le Cancer, Fondation de la Recherche Médicale Française, Ligue de la Recherche contre la Cancer, University of Paris VII, and Ministère de l’Industrie et de la Recherche.

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Authors and Affiliations

  1. Laboratory of Molecular Immunology, CNRS, Institut Jacques Monod, University Paris VII, 2, place Jussieu, F-75251, Paris Cedex 05, France

    A. D. Strosberg, J. G. Guillet, S. Chamat & J. Hoebeke

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  1. A. D. Strosberg
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  2. J. G. Guillet
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  3. S. Chamat
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  4. J. Hoebeke
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  1. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski (Director) (Director)

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4058, Basel, Switzerland

    Fritz Melchers

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Strosberg, A.D., Guillet, J.G., Chamat, S., Hoebeke, J. (1985). Recognition of Physiological Receptors by Anti-Idiotypic Antibodies: Molecular Mimicry of the Ligand or Cross-Reactivity?. In: Koprowski, H., Melchers, F. (eds) Images of Biologically Active Structures in the Immune System. Current Topics in Microbiology and Immunology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70675-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-70675-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

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