Human Antibody Induction to the Idiotypic and Anti-Idiotypic Determinants of a Monoclonal Antibody Against a Gastrointestinal Carcinoma Antigen
Murine monoclonal antibodies (Mab) generated against human tumor antigens (Koprowski and Steplewski 1982) have renewed scientific and clinical interest in passive immunotherapy of human cancer (Kennett et aL 1980). Treatment of B cell leukemias with Mab, for instance, results in immediate reduction of leukemic cells in circulation (Levy and Miller 1983; Ritz et al. 1981). A Mab (17–1A) against an antigen of gastrointestinal cancers (Herlyn et al. 1979) was found to suppress the growth of human tumors in nude mice (Herlyn et al. 1980) and produced significant improvement in the clinical status of a number of patients with metastatic disease (Koprowski 1984a; Sears etal. 1984). As expected, most patients injected with this Mab produced antibody against the murine immunoglobulin (Ig) but, more germaine to this forum, a significant proportion of this antibody was directed against the antigen binding or idiotypic (Id) portion of the molecule (anti-Id) (Koprowski et al. 1984).
KeywordsPeripheral Blood Mononuclear Cell Passive Immunotherapy Rabies Virus Glycoprotein Human Tumor Antigen Antimurine Antibody
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- Bona C, Kohler G (1984) Anti-idiotype antibodies and internal images in monoclonal and antiidiotype antibodies. In: Probes for receptor structure and function. Liss, New YorkGoogle Scholar
- Bona C, Victor-Kobrin C, Manheimer A, Bellon B, Rubenstein L (1984) Regulatory arms of the immune network. In: Idiotypic networks. Immunol Reviews, vol 79. Munksgaard, CopenhagenGoogle Scholar
- Jerne N (1974) Towards a network theory of the immune system. Ann Immunol (Paris) 125C: 373Google Scholar
- Kennett R, Jonak Z, Bechtol K (1980) Monoclonal antibodies against human tumor-associated antigens. In: Monoclonal antibodies. Plenum, New YorkGoogle Scholar
- Koprowski H (1984a) Mouse monoclonal antibodies in vivo. In: Monoclonal antibodies and cancer. Academic, New YorkGoogle Scholar
- Koprowski H (1984b) Human tumor antigens. In: Cancer cells of the transformed phenotype. Cold Spring Harbor, New YorkGoogle Scholar
- Koprowski H, Steplewski Z (1982) Recognition of human tumor antigens by monoclonal antibodies. In: Genes and tumor antigens. Raven, New YorkGoogle Scholar
- Koprowski H, Reagan KJ, Macfarlan RL, Dietzschold D, Wiktor T (1985) A new genertion of rabies vaccines. Rabies glycoprotein gene recombinants, anti-idiotypic antibodies, and synthetic peptides. In: Modern approaches to vaccines. Cold Spring Harbor Symposium, Cold Spring HarborGoogle Scholar
- Lindemann J (1979) Homobodies: do they exist? Ann Immunol (Paris) 130C: 311Google Scholar
- Powe J, Herlyn D, Alavi A, Münz D, Steplewski Z, Koprowski H (1985) Radioimmunodetection of human tumor xenografts by monoclonal antibodies correlates with antibody density and affinity. Proc Eur Assoc Nucleic Med (to be published)Google Scholar