Abstract
The release of acetylcholine (ACh) from myenteric neurons can be regulated by neuronal muscarinic receptors (for review see Kilbinger 1984a). Recent pharmacological and electrophysiological studies suggest that there may exist more than one type of muscarinic receptor on the cholinergic nerves of guinea pig myenteric plexus (Morita et al. 1982a, b; Kilbinger 1984a; Kilbinger and Nafziger 1985). This article evaluates some of the evidence for these claims and discusses some recent experiments on the effects of muscarinic agonists and antagonists on ACh release from guinea pig myenteric plexus.
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References
Barlow RB, Berry KJ, Glenton PAM, Nikolaou NM, Soh KS (1976) A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 °C and in ileum at 29 °C and 37°C. Br J Pharmacol 58: 613–620.
Fuder H, Meiser C, Wormstall H, Muscholl E (1981) The effects of several muscarinic antagonists on pre-and postsynaptic receptors in the isolated heart. Naunyn-Schmiedebergs Arch Pharmacol 316: 31–37.
Fuder H, Rink D, Muscholl E (1982) Sympathetic nerve stimulation on the perfused rat heart. Affinities on N-methylatropine and pirenzepine at pre-and postsynaptic muscarine receptors. Naunyn-Schmiedebergs Arch Pharmacol 318: 210–219.
Fuder H, Kilbinger H, Müller H (1985) Organ selectivity of hexahydrosiladifenidol in blocking pre-and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart. Eur J Pharmacol (to be published).
Hammer R, Giachetti A (1984) Selective muscarinic receptor antagonists. Trends Pharmacol Sci 5: 18–20.
Kilbinger H (1984a) Presynaptic muscarine receptors modulating acetylcholine release. Trends Pharmacol Sci 5: 103–105.
Kilbinger H (1984b) Facilitation and inhibition by muscarinic agonists of acetylcholine release from guinea-pig myenteric neurones: mediation through different types of neuronal muscarine receptors. Trends Pharmacol Sci [Suppl] 5: 49–52.
Kilbinger H, Nafziger M (1985) Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus. Naunyn-Schmiedebergs Arch Pharmacol 328: 304–309.
Kilbinger H, Halim S, Lambrecht G, Weiler W, Wessler I (1984) Comparison of affinities of muscarinic antagonists to pre-and postjunctional receptors in the guinea-pig ileum. Eur J Pharmacol 103:313–320.
Lambrecht G, Moser U, Mutschler E, Wess J, Linoh H, Strecker M, Tacke R (1984) Hexahydrosiladifenidol: a selective antagonist on ileal muscarinic receptors. Naunyn-Schmiedebergs Arch Pharmacol 325: R62.
Marchi M, Paudice P, Raiteri M (1981) Autoregulation of acetylcholine release in isolated hippocampal nerve endings. Eur J Pharmacol 73: 75–79.
Morita K, North RA, Tokimasa T (1982a) Muscarinic agonists inactivate potassium conductance of guinea-pig myenteric neurones. J Physiol 333: 125–139.
Morita K, North RA, Tokimasa T (1982b) Muscarinic presynaptic inhibition of synaptic transmission in myenteric plexus of guinea-pig ileum. J Physiol 333: 141–149.
Mutschler E, Lambrecht G (1984) Selective muscarinic agonists and antagonists in functional tests. Trends Pharmacol Sci [Suppl] 5: 39–44.
Nordström Ö, Alberts P, Westling A, Unden A, Bartfai T (1983) Presynaptic antagonist — postsynaptic agonist at muscarinic cholinergic synapses. Mol Pharmacol 24: 1–5.
Resul B, Dahlbom R, Ringdahl B, Jenden DJ (1982) N-Alkyl-N-(4 tert-amino-l-methyl-2-butynyl) carboxamides, a new class of potent oxotremorine antagonists. Eur J Med Chem 17:317–322.
Schwörer H, Lambrecht G, Mutschler E, Kilbinger H (1985) The effects of racemic bethanechol and its (R)-and (S)-enantiomers on pre-and postjunctional muscarine receptors in the guinea-pig ileum. Naunyn-Schmiedebergs Arch Pharmacol (to be published).
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© 1985 Springer-Verlag Berlin Heidelberg
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Kilbinger, H. (1985). Subtypes of Muscarinic Receptors Modulating Acetylcholine Release from Myenteric Nerves. In: Lux, G., Daniel, E.E. (eds) Muscarinic Receptor Subtypes in the GI Tract. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70668-4_6
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DOI: https://doi.org/10.1007/978-3-642-70668-4_6
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