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The Role of 5′-Nucleotidases in the Heart

  • Conference paper
Book cover Cellular Biology of Ectoenzymes

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

The demand for substrates and oxygen by the heart is closely matched by their supply through coronary circulation. Thus, an increase in force or rate of contraction is powered not by increasing the percentage extraction of substrates and oxygen from the blood but by increasing coronary blood flow (Eckenhoff et al. 1947). Conversely, a decrease in perfusion due to lowered systemic blood pressure or pathologically due to spasm or stenosis of the coronary arteries rapidly leads to an oxygen debt which if not compensated by vasodilation can be detected biochemically through an increase in lactate output, electrically in the E.C.G. and symptomactically through the experience of pain!

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Author information

Authors and Affiliations

  1. Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK

    A. C. Newby

  2. Department of Clinical Biochemistry, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2QR, UK

    Y. Worku

Authors
  1. A. C. Newby
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  2. Y. Worku
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Editor information

Editors and Affiliations

  1. Abt. Neuromorphologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18a, 8033, Martinsried, Germany

    Georg W. Kreutzberg  & Martin Reddington  & 

  2. AK Neurochemie, Zoologisches Institut der Universität, Siesmayerstraße 70, 6000, Frankfurt/M., Germany

    Herbert Zimmermann

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© 1986 Springer-Verlag Berlin Heidelberg

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Newby, A.C., Worku, Y. (1986). The Role of 5′-Nucleotidases in the Heart. In: Kreutzberg, G.W., Reddington, M., Zimmermann, H. (eds) Cellular Biology of Ectoenzymes. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70664-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-70664-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70666-0

  • Online ISBN: 978-3-642-70664-6

  • eBook Packages: Springer Book Archive

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