Skip to main content
SpringerLink
Log in
Book cover

Grundlagen und Erfolgsvorhersage der ambulanten Therapie mit Antidepressiva pp 17–28Cite as

Psychoneuroendokrinologie der Depression

  • Chapter

  • 19 Accesses

Zusammenfassung

In den vergangenen Jahren haben zwei Entwicklungen das Interesse an der Wechselwirkung zwischen psychiatrischen Erkrankungen und hormoneilen Funktionsabläufen neu belegt. Einmal hat die Entwicklung radioimmunologischer Nachweismethoden die Möglichkeit eröffnet, kleinste Hormonmengen in Harn, Blut und Liquor nachzuweisen. Zum anderen hat die neuroendokrinologische Grundlagenforschung Hinweise dafür geliefert, daß Neurotransmitter, wie Noradrenalin, Serotonin, Acetylcholin und Gammaaminobuttersäure in hypothalamischen Arealen die hormoneile Sekretion steuern. Ein gestörter Metabolismus der gleichen Neurotransmitter wird für die Genese der Depression und der Schizophrenie als wesentlicher Faktor erachtet. Die gleichen Transmittersysteme werden auch durch die gebräuchlichen Psychopharmaka beeinflußt, von denen die meisten selbst wieder die hormoneile Sekretion beeinflussen (z.B. Antidepressiva die Kortisolsekretion und Neuroleptika die Prolaktinsekretion). Während vor der Entdeckung der Psychopharmaka das Interesse der Psychiatrie an hormoneilen Regulationsmechanismen vor allem in den therapeutischen Möglichkeiten der Hormone gesucht wurde, liegt der Schwerpunkt der Psychoneuroendokrinologie heute mehr auf der beschreibenden Ebene. So wird versucht, mit Hilfe endokrinologischer Parameter psychiatrische Krankheitsbilder zu charakterisieren (Matussek 1978; Holsboer u. Benkert 1985). Daneben versucht die heutige Psychoneuroendokrinologie auch der Frage nachzugehen, inwieweit durch Messung peripherer Hormone, vor allem im Rahmen endokrinologischer Funktionstests Rückschlüsse auf zentrale Regulationsmechanismen gezogen werden können.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Arana GW, Workman RJ, Baldessarini RJ (1984) Association between low plasma levels of dexamethasone and elevated levels of cortisol in psychiatric patients given dexamethasone. Am J Psychiatry 141: 1619–1620.

    PubMed  CAS  Google Scholar 

  • Asnis GM, Sachar EJ, Halbreich U, Nathan RS, Ostrow L, Halpern PS (1981) Cortisol secretion and dexamethasone response in depression. Am J Psychiatry 138:1218–1221.

    PubMed  CAS  Google Scholar 

  • Baldessarini R, Finklestein S, Arana GW (1983) The predictive power of diagnostic tests and the effect of prevalence of illness. Arch Gen Psychiatry 40:569–573.

    PubMed  CAS  Google Scholar 

  • Bech P, Gjerris A, Anderson J (1983) The melancholia scale and the Newcastle scales: item-combination and inter-observer reliability. Br J Psychiatry 143: 58–63.

    Article  PubMed  CAS  Google Scholar 

  • Beckmann H, Holzmüller B, Fleckenstein P (1984) Clinical investigations into antidepressive mechanisms. II Dexamethasone suppression test predicts response to nomifensine or amitriptyline. Acta Psychiatr Scand 70: 342–353.

    Article  PubMed  CAS  Google Scholar 

  • Berger M, Doerr P, Lund T, Bronisch T, von Zerssen D (1982) Neuroendocrinological and neurophysiological studies in major depressive disorders: Are there biological markers for the endogenous subtype? Biol Psychiatry 17:1217–1242.

    PubMed  CAS  Google Scholar 

  • Berger M, Birke KM, Doerr P, Krieg JC, v. Zerssen D (1984) The limited utility of the dexamethasone suppression test for the diagnostic process in psychiatry. Br J Psychiatry 145: 372–382.

    Article  PubMed  CAS  Google Scholar 

  • Bleuler M (1954) 1. Einleitung: Ziele, Grundlagen und Grenzen. In: Bleuler M (Hrsg) Endokrinologische Psychiatrie. Thieme, Stuttgart, S1–27.

    Google Scholar 

  • Button DR, Koob GF, Rivier J, Vale W (1982) Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci 31: 363–367.

    Article  Google Scholar 

  • Brown WA, Johnston R, Mayfield D (1979) The 24-hour dexamethasone suppression test in a clinical setting: relationship to diagnosis, symp toms and response to treatment. Am J Psychiatry 136:543–547.

    PubMed  CAS  Google Scholar 

  • Cantwell DP, Sturzenberger S, Burroughs J, Salkin B, Green JK (1977) Anorexia nervosa, an affective disorder? Arch Gen Psychiatry 34: 1037–1093.

    Google Scholar 

  • Carroll BJ(1985) Dexamethasone suppression test: a review of contemporary confusion. J Clin Psychiatry (in press).

    Google Scholar 

  • Carroll BJ, Schroeder K, Mukhodpadhyay S, Greden JF, Feinberg M, Ritchie M, Ritchie J, Tarika J (1980) Plasma dexamethasone concentrations and cortisol suppression response in patients with endogenous depression. J Clin Endocrinol Metab 51: 433–437.

    Article  PubMed  CAS  Google Scholar 

  • Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, James N, Kronfol Z, Lohr N, Steiner M, Vigne JPde, Young E(1981) A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38:15–22.

    PubMed  CAS  Google Scholar 

  • Evans DL, Nemeroff CB (1984) Clinical use of the dexamethasone suppression test in DSM III affective disorders. Arch Gen Psychiatry (submitted).

    Google Scholar 

  • Extern I, Pottash ALC, Gold MS, Cowdry RW (1982) Using the protirelin test to distinguish mania from schizophrenia. Arch Gen Psychiatry 39: 77–81.

    Google Scholar 

  • Fang VS, Warenica B, Meltzer HY (1982) Dexamethasone suppression test: technique and accuracy. Arch Gen Psychiatry 39:1217–1218.

    Google Scholar 

  • Galen RS (1983) The predictive value of laboratory diagnoses. Bull Mol Biol Med 8:159–169.

    Google Scholar 

  • Georgotas A, Stokes PE, Krakowski M, Fanelli C, Cooper T (1984) Hypothalamic-pituitary-adreno-cortical function in geriatric depression: diagnostic and treatment implications. Biol Psychiatry 19: 685–693.

    PubMed  CAS  Google Scholar 

  • Gerken A, Maier W, Holsboer F (1985) Weekly monitoring of dexamethasone suppression response in depression: its relationship to change of body weight and psychopathology. Psychoneuroendocrinology (in press).

    Google Scholar 

  • Gold MS, Pottash ALC, Ryan N, Sweeney DR, Davies RK, Martin DM (1980) TRH-induced TSH response in unipolar bipolar and secondary depressions: possible utility in clinical assessment and differential diagnosis. Psychoneuroendocrinology 5:144–155.

    Article  Google Scholar 

  • Greden JF, Gardner R, King D, Grunhaus L, Kronfol Z, Carroll BJ(1983) Dexamethasone suppression tests in antidepressant treatment of melancholia. The process of normalization and test-re-test reproducibility. Arch Gen Psychiatry 40: 493–500.

    PubMed  CAS  Google Scholar 

  • Heimann H (1979) Klinische und psychopathologische Grundlagen. In: Kisker KP, Meyer JE, Müller C, Strömgren E (Hrsg) Psychiatrie der Gegenwart, Forschung und Praxis, Grundlagen und Methoden der Psychiatrie, Teil l. Springer, Berlin Heidelberg New York, S 2–42.

    Google Scholar 

  • Holsboer F, Bender W, Benkert O, Klein HE, Schmauss M (1980) Diagnostic value of dexamethasone suppression test in depression. Lancet I:706.

    Article  Google Scholar 

  • Holsboer F, Liebl R, Hofschuster E (1982a) Repeated dexamethasone suppression test during depressive illness. Normalization of the test result compared with clinical improvement. J Affect Dis 4: 93–101.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F, Winter K, Doerr HG, Sippell WG (1982b) Dexamethasone suppression test in female patients with endogenous depression: determination of plasma corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, cortisol and cortisone. Psychoneuroendocrinology 7: 329–338.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F, Doerr HG, Sippell WG (1982c) Dexamethasone suppression of 11-deoxycorticosterone, corticosterone, and cortisol in depressed female patients and normal controls. Acta Psychiatr Scand 66:18–25.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F (1983) Prediction of clinical course by dexamethasone suppression test (DST) response in depressed patients — physiological and clinical construct validity of the DST. Pharmacopsychiatry 16:186–191.

    Article  CAS  Google Scholar 

  • Holsboer F, Steiger A, Maier W (1983) Four cases of reversion to abnormal dexamethasone suppression test response as indicator of clinical relapse: a preliminary report. Biol Psychiatry 18: 911–916.

    PubMed  CAS  Google Scholar 

  • Holsboer F, Doerr HG, Gerken A, Müller OA, Sippell WG (1984a) Cortisol, 11-deoxycortisol and ACTH-concentrations after dexamethasone in depressed patients and healthy volunteers. Psychiatry Res 11:15–23.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F, Gerken A, Steiger A, Fass V (1984b) The mean 14.00 h-17.00 h plasma cortisol concentration and its relationship to the 1 mg dexamethasone suppression response in depressives and controls. Acta Psychiatr Scand 69: 383–390.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F, Haack D, Gerken A, Vecsei P (1984c) Plasma dexamethasone concentrations and differential glucocorticoid suppression response in depressives and controls. Biol Psychiatry 19: 281–291.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F, Philipp M, Gerken A (1984d) Dexamethasone suppression test (DST) and weight loss. Psychiatry Res 13: 353–354.

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F (1985) Die Entwicklung endokrinologischer Tests in der Depressions-Forschung am Beispiel des Dexamethason-Suppressions-Test. In: Hippius H, Matussek N (Hrsg) Möglichkeiten und Grenzen der Differential-Therapie der Depression. Karger Basel (in press).

    Google Scholar 

  • Holsboer F, Benkert O (1985) Neuroendokrinolo-gische und endokrinologische Forschung bei depressiven Patienten. Nervenarzt 56:1–11.

    PubMed  CAS  Google Scholar 

  • Holsboer F, Gerken A, von Bardeleben U, Grimm W, Stalla GK, Müller OA (1985a) Relationship between pituitary responses to human corticotropin-releasing factor and thyrotropin-releasing hormone in depressives and normal controls. Eur J Pharmacol (in press).

    Google Scholar 

  • Holsboer F, Boll E, Gerken A, Haack D, Klee S, Möller S (1985b) Plasma dexamethasone concentrations after DST during depressive illness and following remission. Psychiatry Res (in press).

    Google Scholar 

  • Kendell RE (1976) The classification of depressions: a review of contemporary confusion. Br J Psychiatry 129:15–28.

    Article  PubMed  CAS  Google Scholar 

  • King D, Dowdy S, Jack R, Gardner R, Edwards P (1982) The dexamethasone suppression test as a predictor of sleep deprivation antidepressant effect. Psychiatry Res 7: 93–99.

    Article  PubMed  CAS  Google Scholar 

  • Langer G, Resch F, Aschauer H, Keshavan MS, Koinig G, Schönbeck G, Dittrich R (1984) TSH-response patterns to TRH stimulation may indicate therapeutic mechanisms of antidepressant and neuroleptic drugs. Neuropsychobiology 11: 213–218.

    Article  PubMed  CAS  Google Scholar 

  • Loosen FT, Frange AJ jr. (1982) Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review. Am J Psychiatry 139:405–416.

    PubMed  CAS  Google Scholar 

  • Lowy MT, Reder AT, Antel JP, Meltzer HY (1984) Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone. Am J Psychiatry 141:1365–1370.

    PubMed  CAS  Google Scholar 

  • Mandell AJ, Chapman LF, Rand RW, Walter RD (1963) Plasma corticosteroids: changes in concentration after stimulation of hippocampus and amygdala. Science 139:1212.

    Article  PubMed  CAS  Google Scholar 

  • Matussek N (1978) Neuroendokrinologische Untersuchungen bei depressiven Syndromen. Nervenarzt 49: 569–575.

    PubMed  CAS  Google Scholar 

  • Money JE(1981) Neuroendocrine control of thyrotropin secretion. Endocr Rev 2: 396–436.

    Google Scholar 

  • Nasrallah HA, Coryell WH(1982) Dexamethasone nonsuppression predicts the antidepressant effects of sleep deprivation. Psychiatry Res 6: 61–64.

    Article  PubMed  CAS  Google Scholar 

  • Peselow BD, Goldring N, Fieve RR, Wright R (1983) The dexamethasone suppression test in depressed outpatients and normal control subjects. Am J Psychiatry 140: 245–247.

    PubMed  CAS  Google Scholar 

  • Philipp M, Maier W, Holsboer F (1985) Psychopath-ological correlates of plasma cortisol after dexamethasone suppression: a polydiagnostic approach. Psychoneuroendocrinology (in press).

    Google Scholar 

  • Reus VI, Joseph MS, Dallman MF (1982) ACTH levels after the dexamethasone suppression test in depression. N Engl J Med 306: 238–239.

    PubMed  CAS  Google Scholar 

  • Rubin RT, Poland RE, Blodgett ALN, Winston RA, Forster B, Carroll BJ (1980) Cortisol dynamics and dexamethasone pharmacokinetics in primary endogenous depression: preliminary findings. In: Brambilla S, Racagni G, de Wied D (eds) Progress in Psychoneuroendocrinology. El-sevier North Holland Biomedicai Press, pp 223–234.

    Google Scholar 

  • Rush J, Giles DE, Roffwarg HP, Parker CR (1382) Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive illness. Biol Psychiatry 17: 327–341.

    Google Scholar 

  • Sachar EJ(1975) Neuroendocrine abnormalities in depressive illness. In: Sachar EJ (ed) Topics in Psychoneuroendocrinology. Grune & Stratton, New York San Francisco London, p 135–156.

    Google Scholar 

  • Stokes PE, Stoll FM, Koslow SH, Maas JW, Davis JM, Swann AC, Robins E (1984) Pretreatment DST and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. Arch Gen Psychiatry 41: 257–267.

    PubMed  CAS  Google Scholar 

  • Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W (1982) Corticotropin releasing factor produces behavioral activation in rats. Nature 297: 331–333.

    Article  PubMed  CAS  Google Scholar 

  • Thomas EB, Levine S, Arnold WJ (1968) Effects of maternal deprivation and incubations rearing upon adrenocortical activity in the adult rat. Dev Psychobiol 1:21–23.

    Article  Google Scholar 

  • Trachsler E, Höchli D, von Luckner N, Woggon B (1985) Dexamethasone suppression test before and after partial sleep deprivation in depressed schizophrenic and schizoaffective patients. Pharmacopsychiatry (in press).

    Google Scholar 

  • Valentino RJ, Foote SL, Aston-Jones G (1983) Corticotropin-releasing factor activates noradrener-gic neurons of the locus coeruleus. Brain Res 270:363–367.

    Article  PubMed  CAS  Google Scholar 

  • Wilens TE, Ritchie JC, Carroll BJ (1984) Comparison of plasma cortisol and corticosterone in the dexamethasone suppression test for melancholia. Psychoneuroendocrinology 9: 45–55.

    Article  PubMed  CAS  Google Scholar 

  • Winokur A, Caroff SN, Amsterdam JD, Maislin G (1984) Administration of thyrotropin-releasing hormone at weekly intervals results in a diminished thyrotropin response. Biol Psychiatry 5:695–702.

    Google Scholar 

Download references

Authors
  1. F. Holsboer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik, Johannes-Gutenberg-Universität, Langenbeckstraße 1, 6500, Mainz, Deutschland

    Michael Philipp

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Holsboer, F. (1985). Psychoneuroendokrinologie der Depression. In: Philipp, M. (eds) Grundlagen und Erfolgsvorhersage der ambulanten Therapie mit Antidepressiva. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70650-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70650-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15717-5

  • Online ISBN: 978-3-642-70650-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation