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EEG and Evoked Potentials in the Diagnosis of Dementias

  • S. L. Visser
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)

Abstract

The EEG in normal adults is characterized by an occipitally dominant 10-Hz alpha rhythm (Fig. 1). The alpha rhythm is reactive, meaning it is attenuated when the eyes are open (Fig. 2) and reappears after eye closure. Even centenarians may have an EEG with a normal alpha rhythm. However, Busse et al. (1956) found that 51% of normal subjects over 60 years of age showed slight EEG abnormalities, mainly focal, in the anterior-temporal regions. The percentage of focal abnormalities increases with age from about 20% in the 40–59-year-old to about 30%–40% in the 60–79-year-old group (Busse and Obrist 1965). These findings have been confirmed by several other authors. The proportion of focal changes in normal aged subjects should not exceed 25% of the EEG record.

Keywords

Visual Evoke Potential Alzheimer Type Senile Dementia Evoke Potential Somatosensory Evoke Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abbott J (1959) The EEG in Jakob-Creutzfeldt’s disease. Electroencephalogr Clin Neurophysiol 11: 184–185Google Scholar
  2. Andermann K, Stoller A (1961) EEG patterns in hospitalized and non-hospitalized aged. Electroencephalogr Clin Neurophysiol 13: 319Google Scholar
  3. Berger H (1933) Ober das Elektrencephalogramm des Menschen V. Arch Psychiatr Nervenkr 98: 231–254CrossRefGoogle Scholar
  4. Brun A, Gustafson L (1978) Limbic lobe involvement in presenile dementia. Arch Psychiatr Nervenkr 226: 79–93PubMedCrossRefGoogle Scholar
  5. Busse EW, Obrist WD (1965) Pre-senescent electroencephalographic changes in normal subjects. J Gerontol 20: 315–320Google Scholar
  6. Busse EW, Barnes RH, Friedman EL, Kelty EJ (1956) Aged individuals with normal and abnormal electroencephalograms. J Nery Ment Dis 124: 135–141CrossRefGoogle Scholar
  7. Cahan RB, Yeager CL (1966) Admission EEG as a predictor of mortality and discharge for aged hospital patients. J Gerontol 21: 248–256PubMedGoogle Scholar
  8. Coben LA, Danziger WL, Berg L (1983 a) Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type. Electroencephalogr Clin Neurophysiol 55: 372–380Google Scholar
  9. Coben LA, Danziger WL, Hughes CP (1983 b) Visual evoked potentials in mild senile dementia of Alzheimer type. Electroencephalogr Clin Neurophysiol 55: 121–130Google Scholar
  10. Cosi V, Vitelli E, Gozzoli L, Corona A, Ceroni M, Callieco R (1982) Visual evoked potentials in aging of the brain. In: Courjon J, Mauguière F, Revol M (eds) Clinical applications of evoked potentials in neurology. Raven, New York, pp 109–115Google Scholar
  11. Dejaiffe G, Constantinidis J, Rey-Bellet J, Tissot R (1964) Corrélations électrocliniques dans les démences de l’âge avancé. Acta Neurol Belg 64: 677–707PubMedGoogle Scholar
  12. Drachman DA, Hughes JR (1971) Memory and the hippocampal complexes. III Aging and temporal EEG abnormalities. Neurology (Minneapolis) 21: 1–14Google Scholar
  13. England AC, Schwab RS, Peterson E (1959) The electroencephalogram in Parkinson’s syndrome. Electroencephalogr Clin Neurophysiol 11: 723–731PubMedCrossRefGoogle Scholar
  14. Friedland RP, Budinger TF, Ganz E, Yano Y, Mathis CA, Koss B, Ober BA, Huesman RH, Derenzo SE (1983) Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose. J Comput Assist Tomogr 7: 590–598PubMedCrossRefGoogle Scholar
  15. Gibbs FA, Gibbs EL (1951) Changes with age, awake. In: Gibbs FA, Gibbs EL (eds) Atlas of electroencephalography, vol I. Methodology and methods. Addison-Wesley, Reading (Mass), pp 82–88Google Scholar
  16. Gloor P, Kalabay O, Giard N (1968) The electroencephalogram in diffuse encephalopathies.Google Scholar
  17. Electroencephalographic correlates of grey and white matter lesions. Brain 91:779–802Google Scholar
  18. Gordon EB, Sim M (1967) The EEG in presenile dementia. J Neurol Neurosurg Psychiatr 30: 285–291PubMedCrossRefGoogle Scholar
  19. Greenblatt M, Levin S, Atwell C (1945) Comparative value of electroencephalogram and abstraction tests in diagnosis of brain damage. J Nery Ment Dis 102: 383–391CrossRefGoogle Scholar
  20. Gustafson L, Risberg J, Hagberg B, Hoigaard K, Nilssen L, Ingvar DH (1972) Cerebral blood flow, EEG and psychometric variables related to clinical findings in presenile dementia. Acta Neurol Scand [Suppl] 51: 439–440Google Scholar
  21. Hendrickson E, Levy R, Post F (1979) Averaged evoked responses in relation to cognitive and affective state of elderly psychiatric patients. Br J Psychiatry 134: 494–501PubMedCrossRefGoogle Scholar
  22. Huisman UW, Posthuma J, Hooijer V, Visser SL, De Rijke W (1985) Somatosensory evoked po-tentials in healthy volunteers and patients with dementia. Clin Neurol Neurosurg 87: 11–16PubMedCrossRefGoogle Scholar
  23. Ingvar DH, Gustafson L (1970) Regional cerebral blood flow in organic dementia with early on-set. Acta Neurol Scand 46 [Suppl] 43: 42–73Google Scholar
  24. Jones DP, Nevin S (1954) Rapidly progressive cerebral degeneration (subacute vascular encephalopathy) with mental disorder, focal disturbances and myoclonic epilepsy. J Neurol Neurosurg Psychiatr 17: 148–159PubMedCrossRefGoogle Scholar
  25. Laidlaw J, Catling J (1964) An EEG assessment of encephalopathy in Parkinsonism. J Neurol Neurosurg Psychiatr 27: 232–236PubMedCrossRefGoogle Scholar
  26. Laurian S, Lobrinus S, Wertheimer J, Gaillard JM (1977) Evoked responses in dementia and the significance of the vertex potential. Electroencephalogr Clin Neurophysiol 43: 525–526Google Scholar
  27. Letemendia F, Pampiglione G (1958) Clinical and EEG observations in Alzheimer’s disease. J Neurol Neurosurg Psychiatr 21: 167–172PubMedCrossRefGoogle Scholar
  28. Levy E, Isaacs A, Behrman J (1971) Neurophysiological correlates of senile dementia. II The somatosensory evoked response. Psychol Med 1: 159–165Google Scholar
  29. Liddell DW (1958) Investigations of EEG findings in presenile dementia. J Neurol Neurosurg Psychiatr 21: 173–176PubMedCrossRefGoogle Scholar
  30. Lundervold A, Engeset A, Lonnum A (1962) The EEG in cerebral atrophy. World Neurol 3: 226–234PubMedGoogle Scholar
  31. McAdam W, Robinson RA (1956) Senile intellectual deterioration and the EEG; quantitative correlation. J Ment Sci 102: 819–825PubMedGoogle Scholar
  32. McEvoy TM, Harkins SW (1981) Brainstem auditory evoked potentials in patients with pre-senile dementia. Abstracts XII Intern Congress Gerontology, Hamburg, vol 2, p 218Google Scholar
  33. Mundy-Castle AC, Hurst LA, Beerstecher DM, Prinsloo T (1954) The electroencephalogram in senile psychoses. Electroencephalogr Clin Neurophysiol 6: 245–252PubMedCrossRefGoogle Scholar
  34. Obrist WD (1954) The electroencephalogram of normal aged adults. Electroencephalogr Clin Neurophysiol 6: 235–244PubMedCrossRefGoogle Scholar
  35. Obrist WD (1963) The EEG of healthy aged males. In: Birren JE, Butler RN, Greenhouse SW, Sokoloff L, Yarrow MR (eds) Human aging: a biological and behavioral study. US Govt Printing Office, Washington PHS Publ No 986, pp 79–93Google Scholar
  36. Obrist WD, Henry CE (1958) Electroencephalographic frequency analysis of aged psychiatric patients. Electroencephalogr Clin Neurophysiol 10: 621–632PubMedCrossRefGoogle Scholar
  37. Obrist WD, Busse EW, Eisdorfer C, Kleemeier RE (1962) Relation of the electroencephalogram to intellectual function in senescence. J Gerontol 17: 197–206PubMedGoogle Scholar
  38. Roberts MA, McGeorge AP, Caird FI (1978) EEG and computerized tomography in vascular and non-vascular dementia in old age. J Neurol Neurosurg Psychiatr 41: 903–906PubMedCrossRefGoogle Scholar
  39. Scott DF, Heathfield KWG, Toone B, Margerison JH (1972) The EEG in Huntington’s chorea: a clinical and neuropathological study. J Neurol Neurosurg Psychiatr 35: 97–102PubMedCrossRefGoogle Scholar
  40. Sisson BD, Ellingson RJ (1956) The EEG in cerebral atrophy. J Nery Ment Dis 123: 244–248CrossRefGoogle Scholar
  41. Soininen H, Partanen VJ, Helkala EL, Riekkinen PJ (1982 a) EEG findings in senile dementia and normal aging. Acta Neurol Scand 65: 59–70Google Scholar
  42. Soininen H, Partanen JV; Puranen M, Riekkinen PJ (1982 b) EEG and computed tomography in the investigation of patients with senile dementia. J Neurol Neurosurg Psychiatry 45: 71 1714Google Scholar
  43. Stoller A (1949) Slowing of the alpha rhythm on the EEG and its association with mental deterioration and epilepsy. J Ment Sci 95: 972–984PubMedGoogle Scholar
  44. Straumanis JJ, Shagass C, Schwartz M (1965) Visually evoked cerebral response changes associated with chronic brain syndromes and aging. J Gerontol 20: 498–506PubMedGoogle Scholar
  45. Visser SL, Stam FC, Van Tilburg W, Op den Velde W, Blom JL, De Rijke W (1976) Visual evoked response in senile and presenile dementia. Electroencephalogr Clin Neurophysiol 40: 385–392PubMedCrossRefGoogle Scholar
  46. Visser SL, Van Tilburg W, Hooijer C, Jonker C, De Rijke W (1985) Visual evoked potentials (VEPs) in senile dementia ( Alzheimer type) and in non-organic behavioural disorders in the elderly; comparison with EEG parameters. Electroencephalogr Clin Neurophysiol 60: 115121Google Scholar
  47. Vogel F, Wendt GG, Oepen H (1961) Das EEG und das Problem einer Frühdiagnose der Chorea Huntington. Dtsch Z Nervenheilk 182:: 355–361Google Scholar
  48. Weiner H, Schuster DB (1956) The electroencephalogram in dementia — some preliminary observations and correlations. Electroencephalogr Clin Neurophysiol 8: 479–488PubMedCrossRefGoogle Scholar
  49. Wright CE, Harding GFA, Orwin A (1984) Presenile dementia — the use of the flash and pattern VEP in diagnosis. Electroencephalogr Clin Neurophysiol 57: 405–415PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • S. L. Visser
    • 1
  1. 1.Department of Clinical NeurophysiologyFree UniversityAmsterdamThe Netherlands

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