Cognitive Deficits in Parkinson’s Disease

  • A. J. Lees
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


Motor abnormalities dominate the clinical picture of Parkinson’s disease. Bradykinesia, caused by severe damage to the ascending nigrostriatal dopaminergic projection, leads to a slight hesitancy in initiating voluntary acts, a difficulty in performing repetitive movements with a progressive reduction in their amplitude, a poorly defined fatigue and possibly an additional defect of motor intention. Many patients also have an inability to attend to two motor commands simultaneously, and more complex perceptual-motor abnormalities have also been detected. Muscle rigidity, a coarse resting tremor and postural instability compound the patient’s incapacities, all of which are exquisitely influenced by the emotions.


Neurol Neurosurg Psychiatry Nucleus Basalis Alzheimer Type Senile Dementia Parkinsonian Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • A. J. Lees
    • 1
  1. 1.Maida Vale HospitalThe National Hospitals for Nervous DiseasesLondonUK

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