Assessment of Cognition and Affective Symptoms in Dementia

  • R. C. Mohs
  • B. S. Greenwald
  • D. D. Dunn
  • K. L. Davis
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


The most prominent symptoms of dementing illnesses are a loss of various cognitive abilities, particularly memory, language, praxis, and judgment. For patients with dementia of the Alzheimer type (DAT), the clinical incidence of these symptoms has been documented in several series, some involving biopsy-proven cases (Coblentz et al. 1973; Sim and Sussman 1962) and other involving clinically diagnosed cases (Liston 1977). Clinical descriptions of patients with proven cases of multiinfarct dementia (MID) have not appeared in great detail, but what evidence is available suggests that there is considerable overlap in the symptoms of DAT and MID (Hachinski et al. 1975; Liston 1977). Thus, any assessment of symptom severity in patients with either of these two kinds of dementia must include measures of memory, language, praxis, and, if possible, judgment.


Depressive Symptom Word Recognition Affective Symptom Dexamethasone Suppression Test Word Recall 
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  1. American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. Washington DCGoogle Scholar
  2. Barker MG, Lawson JS (1968) Nominal aphasia in dementia. Br J Psychiatry 114: 1351–1356PubMedCrossRefGoogle Scholar
  3. Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and senile change in the cerebral gray matter of elderly subjects. Br J Psychiatry 114: 797–811PubMedCrossRefGoogle Scholar
  4. Coblentz JM, Mattis S, Zingesser LH, Kasoff SS, Wisniewski H, Katzman R (1973) Presenile dementia: clinical aspects and evaluation of cerebrospinal fluid dynamics Arch Neurol 29: 299–308Google Scholar
  5. Folstein MF, Folstein S, McHugh P (1975) “Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198Google Scholar
  6. Greenwald BS, Davis BM, Mathé AA, Mohs RC, Levy MI, Johns CA, Davis KL (1985) Cortisol in Alzheimer’s disease. Am J Psychiatry (to be published )Google Scholar
  7. Hachinski VC, Iliff LD, Zilhka E, DuBoulay GH, McAllister VL, Marshall J, Russell RWR, Sy-mon L (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632–637PubMedGoogle Scholar
  8. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56–62PubMedCrossRefGoogle Scholar
  9. Liston EH (1977) Occult presenile dementia. J Nerv Ment Dis 164: 263–267PubMedCrossRefGoogle Scholar
  10. Mohs RC, Greenwald BS, Dunn DD, Johns CA, Davis KL (1985) Assessing change in Alzheimer’s disease: memory and language tasks. In: Poon LW (ed) Clinical assessment of older adults. American Psychological Association, Washington DCGoogle Scholar
  11. Nelson JC, Charney DS (1981) The symptoms of major depressive illness. Am J Psychiatry 138: 1–12PubMedCrossRefGoogle Scholar
  12. Raskind M, Peskind E, Rivard M (1982) Dexamethasone suppression test and cortisol and circadian rhythm in primary degenerative dementia. Am J Psychiatry 139: 1478–1482Google Scholar
  13. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer’s disease. Am J Psychiatry 141: 1356–1364PubMedGoogle Scholar
  14. Roth M, Hopkins B (1953) Psychological test performance in patients over 60: Senile psychosis and affective disorders of old age. J Ment Sci 99: 439–453Google Scholar
  15. Sim M, Sussman I (1962) Alzheimer’s disease: its natural history and differential diagnosis. J Nery Ment Dis 135: 489–499CrossRefGoogle Scholar
  16. Spar JR, Gerner R (1982) Does the dexamethasone suppression test distinguish dementia from depression? Am J Psychiatry 139: 283–240Google Scholar
  17. Wechsler D (1958) Wechsler’s measurement and appraisal of adult intelligence. Williams and Wilkins, BaltimoreCrossRefGoogle Scholar
  18. Zung WWK (1965) A self-rating scale for depression. Arch Gen Psychiatry 12: 63–70PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. C. Mohs
    • 1
  • B. S. Greenwald
    • 1
  • D. D. Dunn
    • 1
  • K. L. Davis
    • 2
  1. 1.Psychiatry Service (116 A)VA Medical Center BronxUSA
  2. 2.Department of PsychiatryMount Sinai School of Medicine New YorkUSA

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