Immunologic Factors Related to Cognitive/Behavioral Dysfunctions in Aging

  • H. Lal
  • M. J. Forster
  • K. Nandy
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


The loss of synapses (Bondareff 1976, 1980), the disappearance of neurotransmitter binding sites (Finch 1982; Lal and Carroll 1979; Severson and Finch 1980), and the mortality of neurons themselves (Colon 1973; Vogel 1969; Johnson and Erner 1972) are conspicuous changes observed in the normally aging mammalian CNS, and they have long been recognized as possible immediate causes for senescence-related declines in the capacity for adaptive behavior of both humans and animals (Landfield 1983; Rapport and Karpiak 1978). Continued research will no doubt further clarify the nature of degenerative changes in the normally aging brain, their contributions to normal senescence-related behavioral changes, and their relevance to senescence-related neuropsychopathology in humans.


Systemic Lupus Erythematosus Avoidance Response Senile Plaque Senile Dementia Immunologic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Lal
    • 1
  • M. J. Forster
    • 1
  • K. Nandy
    • 2
    • 3
  1. 1.Department of PharmacologyTexas College of Osteopathic MedicineFort WorthUSA
  2. 2.Veterans Administration HospitalBedfordUSA
  3. 3.Department of AnatomyBoston University School of MedicineBostonUSA

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