Lesions of the Nucleus Basalis in the Rat: Functional Changes

  • G. Pepeu
  • F. Casamenti
  • L. Bracco
  • H. Ladinsky
  • S. Consolo
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


Kelly and Moore (1978) demonstrated in the rat that an electrolytic lesion of the globus pallidus results in a 50% decrease in choline acetyltransferase (ChAT) activity in the ipsilateral frontal and parietal cerebral cortex. Further evidence for an important cholinergic projection to the neocortex from neurons in the basal forebrain accumulated rapidly thanks to the work of Johnston et al. (1979), Wenk et al. (1979), and Lehman et al. (1980).


Cholinergic Neuron Basal Forebrain Nucleus Basalis Electrolytic Lesion ChAT Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. Pepeu
    • 1
  • F. Casamenti
    • 1
  • L. Bracco
    • 2
  • H. Ladinsky
    • 3
  • S. Consolo
    • 3
  1. 1.Department of PharmacologyUniversity of FlorenceFlorenceItaly
  2. 2.Department of NeurologyUniversity of FlorenceFlorenceItaly
  3. 3.Istituto di Ricerche Farmacologiche “Mario Negri”MilanItaly

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