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Lesions of the Nucleus Basalis in the Rat: Functional Changes

  • Conference paper
Senile Dementia of the Alzheimer Type

Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 2))

Abstract

Kelly and Moore (1978) demonstrated in the rat that an electrolytic lesion of the globus pallidus results in a 50% decrease in choline acetyltransferase (ChAT) activity in the ipsilateral frontal and parietal cerebral cortex. Further evidence for an important cholinergic projection to the neocortex from neurons in the basal forebrain accumulated rapidly thanks to the work of Johnston et al. (1979), Wenk et al. (1979), and Lehman et al. (1980).

This study was supported by CNR grants CT 81.00137.04, 82.02043.04, and 83.02411.04

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Florence, Viale Morgagni 65, 50134, Florence, Italy

    G. Pepeu & F. Casamenti

  2. Department of Neurology, University of Florence, Careggi, 50134, Florence, Italy

    L. Bracco

  3. Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20127, Milan, Italy

    H. Ladinsky & S. Consolo

Authors
  1. G. Pepeu
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  2. F. Casamenti
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  3. L. Bracco
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  4. H. Ladinsky
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  5. S. Consolo
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Editor information

Editors and Affiliations

  1. Neurobiology Department, Troponwerke GmbH & Co. KG, Neurather Ring 1, D-5000, Köln 80, Germany

    Jörg Traber

  2. Division of Molecular Neurobiology Rudolf Magnus Institute for Pharmacology and Institute of Molecular Biology, State University of Utrecht, Padualaan 8, NL-3508 TB, Utrecht, The Netherlands

    Willem Hendrik Gispen

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© 1985 Springer-Verlag Berlin Heidelberg

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Pepeu, G., Casamenti, F., Bracco, L., Ladinsky, H., Consolo, S. (1985). Lesions of the Nucleus Basalis in the Rat: Functional Changes. In: Traber, J., Gispen, W.H. (eds) Senile Dementia of the Alzheimer Type. Advances in Applied Neurological Sciences, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70644-8_25

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  • DOI: https://doi.org/10.1007/978-3-642-70644-8_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70646-2

  • Online ISBN: 978-3-642-70644-8

  • eBook Packages: Springer Book Archive

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