Animal Models of Jacksonian Dissolution of Memory in the Aged
The Jacksonian theory of dissolution of mental function due to injury, disease, or aging states that many infantile behaviors are eventually suppressed by continued growth of the central nervous system and that these functions often reappear following brain injury or dysfunction in adulthood (Jackson 1958). One classic example of this is the Babinski reflex, which is normally present only in infancy but which reappears following some types of brain injury (Willis and Grossman 1973). Senescent decline can also bring about a return of prenatal and infantile reflexes (Paulson 1977). Patients suffering from advanced senile dementia frequently show a return of infantile sucking and grasping reflexes (Paulson and Gottlieb 1968). Such signs do not represent a major part of the symptomatology during the initial phases of dementia, however. Early dementia and other forms of senescent decline are marked by more subtle losses, with the loss of memory seeming to be the commonest and most generally noted.
KeywordsRetention Interval Spatial Memory Passive Avoidance Taste Aversion Conditioned Taste Aversion
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