Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies

  • H. Fraser
  • P. A. McBride
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


Scrapie is a naturally occurring, lethal degeneration of the nervous system of adult sheep, caused by an unconventional, virus-like agent the nature of which has yet to be resolved. Recently, several parallels between experimental models of scrapie in mice and Alzheimer’s disease (AD) have been drawn. Each has a slowly progressing unremitting course and produces lesions confined to the CNS which are largely degenerative, with little evidence of inflammation. Some scrapie models in mice produce pathological features which are highly characteristic of AD, in particular, argyrophilic amyloid plaques and selective neuronal degeneration in the hippocampus (Bruce 1984; Bruce and Dickinson 1982; Bruce and Fraser 1975; Fraser and Bruce 1973; Hyman et al. 1984; Scott and Fraser 1984).


Amyloid Plaque Paired Helical Filament Primary Transmission Scrapie Agent Scrapie Strain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Fraser
  • P. A. McBride
    • 1
  1. 1.AFRC & MRC Neuropathogenesis UnitEdinburghUK

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