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Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies

  • H. Fraser
  • P. A. McBride
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)

Abstract

Scrapie is a naturally occurring, lethal degeneration of the nervous system of adult sheep, caused by an unconventional, virus-like agent the nature of which has yet to be resolved. Recently, several parallels between experimental models of scrapie in mice and Alzheimer’s disease (AD) have been drawn. Each has a slowly progressing unremitting course and produces lesions confined to the CNS which are largely degenerative, with little evidence of inflammation. Some scrapie models in mice produce pathological features which are highly characteristic of AD, in particular, argyrophilic amyloid plaques and selective neuronal degeneration in the hippocampus (Bruce 1984; Bruce and Dickinson 1982; Bruce and Fraser 1975; Fraser and Bruce 1973; Hyman et al. 1984; Scott and Fraser 1984).

Keywords

Amyloid Plaque Paired Helical Filament Primary Transmission Scrapie Agent Scrapie Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bendheim PE, Barry RA, De Armond SJ, Stites DP, Prusiner SB (1984) Antibodies to a scrapie prion protein. Nature 310: 418–421PubMedCrossRefGoogle Scholar
  2. Bruce ME (1984) Scrapie and Alzheimer’s disease. Psychol Med 14: 497–500PubMedCrossRefGoogle Scholar
  3. Bruce ME, Dickinson AG (1982) Dementia and unconventional slow infections. In: Wheatley D (ed) Psychopharmacology of old age, chapter 3. Oxford University Press, Oxford, pp 1523Google Scholar
  4. Bruce ME, Dickinson AG (1979) Biological stability of different classes of scrapie agent. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible disease of the nervous system, vol 2. Academic, New York, pp 71–86Google Scholar
  5. Bruce ME, Fraser H (1975) Amyloid plaques in the brain of mice infected with scrapie: morpho-logical variation and staining properties. Neuropathol Appl Neurobiol 1: 189–202CrossRefGoogle Scholar
  6. Bruce ME, Fraser H (1982) Effects of age on cerebral amyloid plaques in murine scrapie. Neuro-pathol Appl Neurobiol 8: 71–74CrossRefGoogle Scholar
  7. Bruce ME, Dickinson AG, Fraser H (1976) Cerebral amyloidosis in scrapie in the mouse: effect of agent strain and mouse genotype. Neuropathol Appl Neurobiol 2: 471–478CrossRefGoogle Scholar
  8. Collis SC, Kimberlin RH (1983) Further studies on the changes in immunoglobulin G in the sera and CSF of Herdwick sheep with natural and experimental scrapie. J Comp Pathol 93: 331–338PubMedCrossRefGoogle Scholar
  9. Dickinson AG (1976) Scrapie in sheep and goats. In: Kimberlin RH (ed) Slow virus diseases of animals and man, chapter 10. Elsevier, Amsterdam, pp 209–241Google Scholar
  10. Dickinson AG, Fraser H (1977) Scrapie: pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent, chapter 1. In: Ter Meulen V, Katz M (eds) Springer, Berlin Heidelberg New York, pp 3–14Google Scholar
  11. Dickinson AG, Fraser H, Outram GW (1975) Scrapie incubation period time can exceed natural lifespan. Nature 256: 732–733PubMedCrossRefGoogle Scholar
  12. Diringer H, Gelderblom, Hilmert H, Ozel M, Edelbluth C, Kimberlin RH (1983) Scrapie infectivity, fibrils and low molecular weight protein. Nature 306: 476–478PubMedCrossRefGoogle Scholar
  13. Diringer H, Ralm HC, Bode L (1984) Antibodies to proteins of scrapie-associated fibrils. Lancet II:345CrossRefGoogle Scholar
  14. Fraser H (1979) Neuropathology of scrapie: The precision of the lesions and their diversity. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 1. Academic, New York, pp 387–405Google Scholar
  15. Fraser H (1983) A survey of primary transmission of Icelandic scrapie (rida) to mice. In: Court LA, Cathala F (eds) Virus non conventionnels et affections du système nerveux central, chapter 3. Masson, Paris, pp 34–46Google Scholar
  16. Fraser H, Bruce ME (1973) Argyrophilic plaques in mice inoculated with scrapie from particular sources. Lancet I:617–618CrossRefGoogle Scholar
  17. Fraser H, Bruce ME (1983) Experimental control of cerebral amyloid in scrapie in mice. In: Behan PO, ter Meulen V, Clifford Rose F (eds) Immunology of nervous system infections; progress in brain research. Elsevier, Amsterdam, pp 281–289CrossRefGoogle Scholar
  18. Gardiner AC, Marucci AA (1969) Immunological responsiveness of scrapie-infected mice. J Comp Pathol 79: 233–235PubMedCrossRefGoogle Scholar
  19. Hourrigan J, Klingspoorn A, Clark WW, de Camp M (1979) Epidemiology of scrapie in the United States. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 1. Academic, New York, pp 331–356Google Scholar
  20. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation. Science 225: 1168–1170PubMedCrossRefGoogle Scholar
  21. Masters CL, Gajdusek DC, Gibbs CJ, Bernoulli C, Asher DM (1979) Familial Creutzfeldt-Jakob disease and other familial dementias: an inquiry into possible modes of transmission of virus-induced familial diseases. In: Prusiner SB, Hadlow WJ (eds) Slow transmissible diseases of the nervous system, vol 1. Academic, New York, pp 143–194Google Scholar
  22. McKinley MP, Bolton DC, Prusiner SB (1983) A protease-resistant protein is a structural component of the scrapie prion. Cell 35: 57–62PubMedCrossRefGoogle Scholar
  23. Merz PA, Somerville RA, Wisniewski HM, Iqbal K (1981) Abnormal fibrils from scrapie-infected brain. Acta Neuropathol 54: 63–74PubMedCrossRefGoogle Scholar
  24. Merz PA, Somerville RA, Wisniewski HM ( 1983 a) Abnormal fibrils in scrapie and senile dementia of Alzheimer type. In: Court LA, Cathala F (eds) Virus non conventionnels et affections du système nerveux central, chapter 21. Masson, Paris, pp 259–281Google Scholar
  25. Merz PA, Somerville RA, Wisniewski HM, Manuelides L, Manuelides EE (1983 b) Scrapie-associated fibrils in Creutzfeld-Jakob disease. Nature 306:474–476PubMedCrossRefGoogle Scholar
  26. Porter DD, Porter HG, Cox NA (1973) Failure to demonstrate a humoral immune response to scrapie in mice. J Immunol 111: 1407–1410PubMedGoogle Scholar
  27. Prusiner SB (1984) Some speculations about prions, amyloid, and Alzheimer’s disease. N Engl J Med 310: 661–663PubMedCrossRefGoogle Scholar
  28. Scott JR, Fraser H (1984) Degenerative hippocampal pathology in mice infected with scrapie. Acta Neuropathol 65: 62–68PubMedCrossRefGoogle Scholar
  29. Sobel H (1970) Ageing and age-associated disease. Lancet II:1191–1192Google Scholar
  30. Wisniewski HM, Bruce ME, Fraser H (1975) Infectious etiology of neuritic (senile) plaques in mice. Science 190: 1108–1110PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Fraser
  • P. A. McBride
    • 1
  1. 1.AFRC & MRC Neuropathogenesis UnitEdinburghUK

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