Melanocortin Peptides and Neural Plasticity
The term melanocortin peptides is used to describe peptides related to the pituitary hormones, adrenocorticotrophic hormone (ACTH) and melanophorestimulating hormones (α- and β-MSH). The amino acid sequences of these hormones, together with other biologically active peptides such as β-endorphin, are contained within a common precursor, proopiomelanocortin (POMC) (Fig. 1).
KeywordsSciatic Nerve Neural Plasticity Sciatic Nerve Crush Trophic Action Synaptic Efficiency
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- Edwards PM, Schrama LH, Spierings T, Verhaagen J, Schotman P, Gispen WH (1984b) Presence of melanotropic activity in degenerating nerve extracts. Possible connection with generation of neurotrophic factors by neurofilament protein breakdown. Neurosci Lett [Suppl] 18:S89Google Scholar
- Edwards PM, Spierings T, Verhaagen J, Terlou M (1984c) A quantitative micromethod for 2-dimensional analysis of proteins in whole tissue extracts. Neurosci Lett [Suppl] 18:S331Google Scholar
- Kamakura K, Ihara Y, Sugita H, Toyokura Y (1981) Inhibition by E-64-c of neurofilament degeneration induced by calcium ions. Biomed Res 2:327–329Google Scholar
- Landfield PW (1983) Mechanisms of altered neural function during aging. Dev Neurol 7:51–71Google Scholar
- Soifer D, Iqbal K, Czosnek H, de Martini J, Sturman JA, Wisniewski HM (1981) The loss of neuron-specific proteins during the course of Wallerian degeneration of optic and sciatic nerve. J Neurosci 5:461–470Google Scholar