The Nature of Neurofibrillary Tangles

  • B. H. Anderton
  • M. C. Haugh
  • J. Kahn
  • C. Miller
  • A. Probst
  • J. Ulrich
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


Dementia of the Alzheimer type (ATD), both presenile and senile, has a characteristic brain histopathology comprising neurofibrillary tangles (NFT), senile plaques, granulovacuolar bodies and Hirano bodies. Alzheimer-type NFT are also found in several other diseases, including Down’s syndrome, postencephalitic Parkinson’s disease, dementia pugilistica, subacute sclerosing panencephalitis, Parkinson-dementia complex and Hallevorden-Spatz syndrome (Wisniewski et al. 1979). In ATD, NFT are found in certain cortical and subcortical neuronal perikarya and consist of aggregates of abnormal fibres.


Sodium Dodecyl Sulphate Neurofibrillary Tangle Senile Dementia Subacute Sclerosing Panencephalitis Paired Helical Filament 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. H. Anderton
    • 1
  • M. C. Haugh
    • 1
  • J. Kahn
    • 2
  • C. Miller
    • 1
  • A. Probst
    • 3
  • J. Ulrich
    • 3
  1. 1.Department of Immunology, St. George’s Hospital Medical SchoolUniversity of LondonLondonUK
  2. 2.Department of Neuropathology, Institute of PsychiatryUniversity of LondonLondonUK
  3. 3.Department of Neuropathology, Institute of PathologyUniversity of BaselBaselSwitzerland

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