Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies
Although recent progress in the isolation of neurofibrillary tangles (NFT) has been made (Ihara et al. 1983; Iqbal et al. 1984), little information is available on the biochemical nature of NFT, their precise relationship with neuron organelles and their etiopathogenesis. Difficulties in carrying out the biochemical analysis of NFT until now have been attributed to their unusual insolubility (Selkoe et al. 1982), although this property also seems a matter of debate (Iqbal et al. 1984). Ultrastructural studies have also clearly pointed out their unique morphological features (Terry 1963; Kidd 1963) Immunohistochemistry offers an interesting approach, since well-defined antibodies reacting with NFT in tissue sections (Anderton et al. 1982; Gambetti et al. 1983) have recently been described.
KeywordsNeurofibrillary Tangle Senile Plaque Alzheimer Type Senile Dementia Paired Helical Filament
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