Investigation of Regional Cerebral Blood Flow and Metabolism in Dementia

  • W.-D. Heiss
  • G. Pawlik
  • K. Herholz
  • B. Szelies
  • C. Beil
  • K. Wienhard
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 2)


Age-related disorders of the brain like the dementias may be caused by primary disturbances of cerebral blood flow (CBF) or of metabolism. Due to the coupling of functional activity and metabolism, impairment of higher brain function, on the other hand, may lead to a secondary decrease in physiologic variables. Therefore, investigation of CBF and metabolism of various substrates is useful for the detection of such brain disorders and may additionally yield quantifiable data on the severity of the disease. Such quantitative results can be used for a variety of purposes: to monitor the course of the disease in the patient, to formulate prognoses, and to constitute a basis for the objective comparison of various therapeutic protocols. During the last 40 years, various methods for the measurement of CBF and metabolism have been developed.


Positron Emission Tomography Cerebral Blood Flow Regional Cerebral Blood Flow Cereb Blood Flow Degenerative Dementia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • W.-D. Heiss
  • G. Pawlik
  • K. Herholz
  • B. Szelies
  • C. Beil
  • K. Wienhard
    • 1
  1. 1.Max-Planck-Institut für neurologische ForschungKöln 91 (Merheim)Germany

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