Effects of Amosite Fibers of Different Sizes on Lavagable Cells and Epithelial Permeability of the Lung
Several investigators have studied the correlation between physical dimensions of asbestos fibers and their carcinogenic potency (e.g. Stanton and Wrench 1972; Pott and Friedrichs 1972; Wagner et al. 1973) and it has been hypothesized that asbestos fibers above 8 urn in length and below 1.5 μm in diameter are most effective in inducing tumors (Stanton et al. 1977). The validity for using fiber dimensions to describe their biological activity has been corroborated by findings about the induction of mesotheliomas in experimental animals by fibers of different composition. Those finding were the basis for the concept of durability of fibrous dusts in the tissue in addition to their physical dimensions to predict their long-term effects (Pott 1978; Stanton et al. 1977). Additional studies have also indicated the importance of fiber geometry for the development of asbestosis and for the acute in vitro toxicity of fibers (e.g. Beck et al 1971; Johnson and Davies 1980; Tilkes and Beck 1980). Greater fiber length seems to be correlated with greater toxicity both in vitro and in vivo (Chamberlain et al. 1980).
KeywordsFiber Fraction Mineral Dust Asbestos Fiber Epithelial Permeability Mineral Fiber
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- Ayars GH, Altman LC, Rosen H and Doyle T (1984) The injurious effect of neutrophils on pneumocytes in vitro. Am Rev Resp Dis 130: 964–973Google Scholar
- Beck EG, Bruck J, Friedrichs KG, Hilscher W and Pott F (1971) Fibrous silicates in animal experiments and cell culture - morphological cell and tissue reactions according to different physical chemical influences. In: Walton WH, Inhaled Particles III, Gresham Press, England, p477Google Scholar
- Chamberlain M, Brown RC and Griffiths DM (1980) The correlation between the carcinogenic activities in vivo and the cytopathic effect in vitro of mineral dusts. In: Brown RC, Gormley IP, Chamberlain M, Davies R (eds) The In Vitro Effects of Mineral Dusts, Academic Press, London, p345Google Scholar
- Johnson NF and Davies R (1980) The effect of crocidolite on peritoneal macrophages: A study by transmission and scanning electron microscopy. In: Brown RC, Gormley IP, Chamberlain M, Davies R (eds) The In Vitro Effects of Mineral Dusts, Academic Press, London, p97Google Scholar
- Pott F (1978) Some aspects on the dosimetry of the carcinogenic potency of asbestos and other fibrous dusts. Staub Reinhalt Luft 38: 486–489Google Scholar
- Tilkes F and Beck EG (1980) Comparison of length-dependent cytotoxicity of inhalable asbestos and manmade mineral fibers. In: Wagner JC (ed) Biological Effects of Mineral Fibers, IARC Sci Publ 1(30), International Agency for Research on Cancer, Lyon, p478Google Scholar