Abstract
The present work was undertaken to investigate the biological activity of a series on mineral fibers, namely chrysotile asbestos and some of its major substitutes. Our main purpose was to examine and compare the behavior of these materials at the cellular level, in particular with respect to the mechanisms involved in the process of carcinogenesis. Our strategy was based upon the two-stage model of carcinogenesis (Weisberger and Williams 1982). At first our attention focused on the initiation stage. Direct induction of genotoxic effects or modulation of effects by known genotoxic agents were tested for chrysotile asbestos UICC B, attapulgite, xonotlite and sepiolite. For this purpose, a well-established cellular model designed for the detection of genotoxic properties was selected. With this model, DNA damage caused by genotoxic agents in primary hepatoxyte cultures can be evaluated through the measurement of unscheduled DNA synthesis (UDS) (Williams 1980).
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References
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© 1985 Springer-Verlag Berlin Heidelberg
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Denizeau, F., Marion, M., Fleury, J., Chevalier, G., Côté, M.G. (1985). Genotoxic Effects of Natural and Man-made Mineral Fibers. In: Beck, E.G., Bignon, J. (eds) In Vitro Effects of Mineral Dusts. NATO ASI Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70630-1_33
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DOI: https://doi.org/10.1007/978-3-642-70630-1_33
Publisher Name: Springer, Berlin, Heidelberg
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