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Transformation of Mammalian Cells in Culture by Asbestos and Other Mineral Dusts: A Mechanism Involving Chromosomal Mutation

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In Vitro Effects of Mineral Dusts

Part of the book series: NATO ASI Series ((ASIG,volume 3))

Abstract

The mechanisms by which asbestos fibers induce cancer are unknown. This is attributable in part to the lack of an in vitro system to study the process of asbestos-induced neoplastic transformation. We have recently reported that mineral dusts induce the morphological transformation of Syrian hamster embryo cells in culture (Hesterberg and Barrett 1984). Others have also shwon induction of cell transformation by asbestos (DiPaolo et al. 1983; Lechner et al., this volume; Patérour et al., this volume).

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References

  • Babu KA, Nigam SK, Lakkad BC, Bhatt DK, Karnik AB, Thakore KN, Kashyap SK, Chatterjee SK (1981) Effect of chrysotile asbestos (AP-I) on sister chromatid exchanges in Chinese hamster ovary cells. Environ Res 24: 325–329

    Article  CAS  Google Scholar 

  • Benedict WF, Rucker N, Mark C, Kouri R (1975) Correlation between balance of specific chromosomes and expression of malignancy in hamster cells. J Natl Cancer Inst 54: 157–162

    PubMed  CAS  Google Scholar 

  • Buckton KK, Evans HJ (1982) Human peripheral blood lymphocyte cultures: An in vitro assay for the cytogenetic effects of environmental mutagens. In: Hsu TC (ed) Cytogenetic assay of environmental mutagens. Allanheld, Osmun, New Jersey, p183–202

    Google Scholar 

  • Casey G (1983) Sister chromatid exchange and cell kinetics in CH0-K1 cells, human fibroblasts and lymphoblastoid cells exposed in vitro to asbestos and glass fibre. Mut Res 116: 369–377

    Article  CAS  Google Scholar 

  • Chamberlain M, Brown RC (1978) The cytotoxic effects of asbestos and other mineral dust in tissue culture cell lines. Brit J Exp Path 59: 183–189

    PubMed  CAS  Google Scholar 

  • Chamberlain M, Tarmy EM (1977) Asbestos and glass fibers in bacterial mutation tests. Mutation Res 43: 159–164

    Article  PubMed  CAS  Google Scholar 

  • DiPaolo JA, DeMarinis AJ, Doniger J (1983) Asbestos and benzo(a)pyrene synergism in the transformation of Syrian hamster embryo cells. Pharmacology 27: 65–73

    Google Scholar 

  • Hesterberg TW, Barrett JC (1985) Induction by abestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Carcinogenesis (In Press)

    Google Scholar 

  • Hesterberg TW, Barrett JC (1984) Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res 44: 2170–2180

    PubMed  CAS  Google Scholar 

  • Hesterberg TW, Oshimura M, Brody AR, Barrett JC (1985) Asbestos and silica induce morphological transformation of mammalian cells in culture: a possible mechanism. In: Goldsmith DF, Shy CM, Winn DM (eds) Silica, Silicosis and Cancer: Controversy in Occupational Medicine. Praeger Press, Philadelphia (In Press)

    Google Scholar 

  • Harington JS (1981) Fiber carcinogenesis: epidemiologic observations and the Stanton hypothesis. J Natl Cancer Inst 67: 977–987

    PubMed  CAS  Google Scholar 

  • Huang SL, Saggioro D, Michelmann H, Mailing HV (1978) Genetic effects of crocidolite asbestos in Chinese hamster lung cells. Mutat Res 57: 225–232

    CAS  Google Scholar 

  • Jaurand MC, Bastie-Sigeac I, Bignon J, Stoebner P (1983) Effect of chrysotile and crocidolite on the morphology and growth of rat pleural mesothelial cells. Environ Res 30: 255–269

    Article  PubMed  CAS  Google Scholar 

  • Kaplan H, Renier A, Jaurand MC, Bignon J (1980) Sister chromatid exchanges in mesothelial cells cultured with chrysotile fibers. In: Brown RC et al. (eds) The In Vitro Effects of Mineral Dusts, Academic Press, New York, p251–253

    Google Scholar 

  • Lavappa KS, Fu MM, Epstein SS (1975) Cytogenetic studies on chrysotile asbestos. Environ Res 10: 165–173

    Article  PubMed  CAS  Google Scholar 

  • Livingston GK, Rom WN, Morris MV (1980) Asbestos-induced sister chromatid exchanges in cultured Chinese hamster ovarian fibroblast cells. J Envir Pathol Toxicol 4: 373–382

    CAS  Google Scholar 

  • Oshimura M, Hesterberg TW, Tsutsui T, Barrett JC (1984) Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. Cancer Res 44: 5017–5022

    PubMed  CAS  Google Scholar 

  • Perry P, Evans HJ (1975) Cytological detection of mutagen-carcinogen exposure by sister chromatid exchanges. Nature 258: 121–125

    Article  PubMed  CAS  Google Scholar 

  • Perry P, Wolf S (1974) New Giemsa method for the differential staining of sister chromatids. Nature 251: 156–158

    Article  PubMed  CAS  Google Scholar 

  • Reiss B, Solomon S, Weisburger JH, Williams GM (1980) Comparative toxicities of different forms of asbestos in a cell culture assay. Environ Res 22: 109–129

    Article  PubMed  CAS  Google Scholar 

  • Sasaki M (1982) Role of chromosomal mutation in the development of cancer. Cancer Genet Cytogenet 33: 160–168

    Article  CAS  Google Scholar 

  • Sincock AM (1977) Preliminary studies of the in vitro cellular effects of asbestos and fine glass dusts. In: Hiatt HH, Watson JD, Winsten JA (eds) Origin of human cancer (B). Cold Spring Harbor Laboratory, p941–954

    Google Scholar 

  • Sincock AM, Seabright M (1975) Induction of chromosome changes in Chinese hamster cells by exposure to asbestos fibers. Nature 257: 56–58

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto T, Rabinowitz Z, Sachs L (1973) Identification of the chromosomes that control malignancy. Nature New Biol 243: 247–250

    PubMed  CAS  Google Scholar 

  • Yunis JJ (1983) The chromosomal basis of human neoplasia. Science 221: 227–236

    Article  PubMed  CAS  Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Hesterberg, T.W., Oshimura, M., Barrett, J.C. (1985). Transformation of Mammalian Cells in Culture by Asbestos and Other Mineral Dusts: A Mechanism Involving Chromosomal Mutation. In: Beck, E.G., Bignon, J. (eds) In Vitro Effects of Mineral Dusts. NATO ASI Series, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70630-1_23

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  • DOI: https://doi.org/10.1007/978-3-642-70630-1_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70632-5

  • Online ISBN: 978-3-642-70630-1

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