Cardiopulmonary System Responses to Muscular Exercise in Man

  • B. J. Whipp
  • S. A. Ward
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Muscular exercise can only be performed at the expense of energy stores which are readily accessible to the contractile mechanisms of skeletal muscle; specifically, through the utilization of the free energy of hydrolysis of ATP. Intramuscular ATP concentrations are themselves maintained at the expense of creatine phosphate breakdown and through increased rates of ATP production resulting from aerobic or anaerobic metabolism.

Keywords

Fatigue Hydrolysis Lactate Respiration Expense 

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References

  1. Bakker HK, Struikenkamp RS, De Vries GA (1980) Dynamics of ventilation, heart rate, and gas exchange: sinusoidal and impulse work loads in man. J Appl Physiol 48: 289–301PubMedGoogle Scholar
  2. Bennett FM, Tallman RD, Grodins FS (1984) Role of VC02 in eontrol of breathing of awake dogs. J Appl Physiol 56: 1335–1337PubMedGoogle Scholar
  3. Biscoe TJ (1977) The carotid body. What next? Am Rev Respir Dis 115: 189–191PubMedGoogle Scholar
  4. Black AMS, McCloskey DI, Torrance RW (1971) The response of carotid chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli. Respir Physiol 13: 36–49PubMedCrossRefGoogle Scholar
  5. Black AMS, Goodman NW, Nail BS, Rao PS, Torrance RW (1973) The significance of the timing of chemoreceptor impulses for their effect upon respiration. Acta Neurobiol Exp 33: 139–147Google Scholar
  6. Casaburi R, Whipp BJ, Wasserman K, Stremel RW (1978) Ventilatory control characteristics of the exercise hyperpnea as discerned from dynamic forcing techniques. Chest 73S: 280S–283SGoogle Scholar
  7. Cross BA, Davey A, Guz A, Katona PG, Maclean M, Murphy K, Semple SJG, Stidwell R (1982) The pH oscillations in arterial blood during exercise; a potential signal for the ventilatory response in the dog. J Physiol (Lond) 329: 57–73Google Scholar
  8. Cunningham DJC (1974) The control system regulating breathing in man. Q Rev Biophys 6: 433–483CrossRefGoogle Scholar
  9. Cunningham DJC (1975) A model illustrating the importance of timing in the regulation of breathing. Nature 253: 440–442PubMedCrossRefGoogle Scholar
  10. Davies CTM, Di Prampero PE, Cerretelli P (1972) Kinetics of cardiac output and respiratory gas exchange during exercise and recovery. J Appl Physiol 32: 618–625PubMedGoogle Scholar
  11. Dejours P (1964) Control of respiration in muscular exercise. In: Rahn H, Fenn WO (eds) Respiration. Handbook of Physiology, vol I. Am Physiol Soc, Washington DC, pp 631–648Google Scholar
  12. Dejours P (1967) Neurogenic factors in the control of ventilation during exercise. Cire Res 10–21 (suppl) 1: I146–I153Google Scholar
  13. Dempsey JA, Mitchell GS, Smith CA (1984) Exercise and chemoreception. Am Rev Respir Dis 129 (Suppl): S31–S34PubMedGoogle Scholar
  14. Eldridge FL (1972) The importance of timing on the respiratory effects of intermittent carotid body chemoreceptor stimulation. J Physiol (Lond) 222: 319–333Google Scholar
  15. Eldridge FL (1977) Maintenance of respiration by central neural feedback mechanisms. Fed Proc 36: 2400–2404PubMedGoogle Scholar
  16. Eldridge FL, Gill-Kumar P (1980) Mechanisms of hyperpnea induced by isoproterenol. Respir Physiol 40: 349–363PubMedCrossRefGoogle Scholar
  17. Eldridge FL, Millhorn DE, Waldrop TG (1981) Exercise hyperpnea and locomotion: parallel activation from the hypothalamus. Science 211: 844–846PubMedCrossRefGoogle Scholar
  18. Folinsbee LJ, Wallace ES, Bedi JF, Horvath SM (1983) Respiratory pattern in trained athletes. In: Whipp BJ, Wiberg DM (eds) Elseiver, New York, pp 205 –212Google Scholar
  19. Fordyce WE, Bennett FM (1984) Some characteristics of a steady state model of exercise hyperpnea. Physiologist 27 (4): 217Google Scholar
  20. Green JF, Sheldon MI (1983) Ventilatory changes associated with changes in pulmonary blood flow in dogs. J Appl Physiol 54: 997–1002PubMedCrossRefGoogle Scholar
  21. Griffiths TG, Henson LC, Huntsman D, Wasserman K, Whipp BJ (1980) The influence of inspired 02 partial pressure on ventilatory and gas exchange kinetics during exercise. J Physiol (Lond) 306: 34 PGoogle Scholar
  22. Guyton AC, Jones CE, Coleman TG (1973) Circulatory physiology: Cardiac output and its regulation. Saunders, Philadelphia, chapt 25Google Scholar
  23. Hagberg JM, Coyle EF, Carroll JE, Miller JM, Martin WH, Brooke MH (1982) Exercise hyperventilation in patients with McArdle’s disease. J Appl Physiol 52: 991–994PubMedGoogle Scholar
  24. Herxheimer H, Kost R (1932) Das Verhältnis von Sauerstoffaufnahme und Kohlensäureausscheidung zur Ventilation bei harter Muskelarbeit, Z Klin Med 108: 240–247Google Scholar
  25. Huszczuk A, Jones PW, Wasserman K (1981) Pressure information from the right ventricle as a reflex coupler of ventilation and cardiac output. Fed Proc 40: 568Google Scholar
  26. Huszczuk A, Jones PW, Oren A, Shors EC, Nery LE, Whipp BJ, Wasserman K (1983) Venous return and ventilatory control. In: Whipp BJ, Wiberg DM (eds) Modelling and control of breathing. Elsevier, New York, pp 78–85Google Scholar
  27. Jensen JI (1972) Neural ventilatory drive during arm and leg exercise. Scand J Clin Lab Invest 29: 177–184PubMedCrossRefGoogle Scholar
  28. Jones NL (1975) Exercise testing in pulmonary evaluation: rationale, methods, and the normal respiratory response to exercise. N Engl J Med 293: 541–544PubMedCrossRefGoogle Scholar
  29. Jones PW, Huszczuk A, Wasserman K (1982) Cardiac output as a controller of ventilation through changes in right ventricular load. J Appl Physiol 53: 218–244PubMedCrossRefGoogle Scholar
  30. Juratsch CE, Huszczuk A, Gianotta S, Whipp BJ (1981) Evidence for a ‘cardiodynamic’ component of the isoproterenol induced hyperpnea in the dog. Fed Proc 40: 567Google Scholar
  31. Kan WO, Ledsome JR, Boiter CP (1979) Pulmonary arterial distension and activity in phrenic nerve of anesthetized dogs. J Appl Physiol 46: 625–631PubMedGoogle Scholar
  32. Kao FF (1963) An experimental study of the pathways involved in exercise hyperpnea employing cross-circulation techniques. In: Cunningham DJC, Lloyd BB (eds) The regulation of human respiration. Blackwell, Oxford, pp 461–502Google Scholar
  33. Karlsson H, Lindborg B, Linnarsson D (1975) Time courses of pulmonary gas exchange and heart rate changes in supine exercise. Acta Physiol Scand 95: 329–340PubMedCrossRefGoogle Scholar
  34. Kostreva DR, Hopp FA, Zuperku EJ, Kampine JP (1979) Apnea, tachycardia and hypertension elicited by cardiac vagal afferents. J Appl Physiol 47: 312–318PubMedGoogle Scholar
  35. Krogh A, Lindhard J (1913) The regulation of respiration and circulation during the initial stages of muscular work. J Physiol (Lond) 47: 112–136Google Scholar
  36. Lewis SM (1975) Awake baboon’s ventilatory response to venous and inhaled CO2 loading. J Appl Physiol 39: 417–422PubMedGoogle Scholar
  37. Linnarsson D (1974) Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol Scand (Suppl) 415: 1–68Google Scholar
  38. Lloyd TC Jr (1984) Effect on breathing of acute pressure rise in pulmonary artery and right ventricle. J Appl Physiol 57: 110–116PubMedGoogle Scholar
  39. McCloskey DI, Mitchell JH (1972) Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol (Lond) 224: 173–186Google Scholar
  40. Miyamoto Y, Nakazono Y, Hiura T, Abe Y (1983) Cardiorespiratory dynamics during sinusoidal and impulse exercise in man. Jpn J Physiol 33: 971–986PubMedCrossRefGoogle Scholar
  41. Oren A, Whipp BJ, Wasserman K (1982) Effect of acid-base status on the kinetics of the ventilatorY response to moderate exercise. J Appl Physiol 52: 1013–1017PubMedGoogle Scholar
  42. Phillipson EA, Bowes G, Townsend ER, Duffin J, Cooper JD (1981) Role of metabolic CO2 production in ventilatory response to steady-state exercise. J Clin Invest 68: 768–774PubMedCrossRefGoogle Scholar
  43. Saunders KB (1980) Oscillations of arterial CO2 tension in a respiratory model: some implications for the control of breathing in exercise. J Theor Biol 84: 163–181PubMedCrossRefGoogle Scholar
  44. Shors EC, Huszczuk A, Wasserman K, Whipp BJ (1983) Effects of spinal-cord section and altered lung CO2 flow on the exercise hyperpnea in the dog. In: Whipp BJ, Wiberg DM (eds) Modelling and control of breathing. Elsevier, New York, pp 274–281Google Scholar
  45. Stockley RA (1978) The contribution of the reflex hypoxic drive to the hyperpnea of exercise.Respir Physiol 35: 79–87Google Scholar
  46. Stremel RW, Huntsman DJ, Casaburi R, Whipp BJ, Wasserman K (1978) Control of ventilation during intraveous CO2 loading in the awake dog. J Appl Physiol 44: 311–316PubMedGoogle Scholar
  47. Stremel RW, Whipp BJ, Casaburi R, Huntsman DJ, Wasserman K (1979) Hypopnea consequent to diminished blood flow in the dog. J Appl Physiol 46: 1171–1177PubMedGoogle Scholar
  48. Tibes U (1977) Reflex inputs to the cardiovascular and respiratory centers from dynamically working canine muscles. Cire Res 41: 332–341Google Scholar
  49. Torrance RW (1974) Arterial chemoreceptors. In: Widdicombe JG (ed) Respiration, MTP Int Rev Sci, Ser one, Physiol vol 2. Butterworths, London, pp 247–271Google Scholar
  50. Waldrop TG, Rybicki KJ, Kaufman MP (1984) Chemical activation of group I and group II muscle afferents has no cardiorespiratory effects. J Appl Physiol 56: 1223–1228PubMedGoogle Scholar
  51. Wasserman DH, Whipp BJ (1983) Coupling of ventilation to pulmonary gas exchange during non-steady-state work in men. J Appl Physiol 54: 587–593PubMedGoogle Scholar
  52. Wasserman K, Whipp BJ (1976) The carotid bodies and respiratory control in man. In: Paintal AS (ed) Morphology and mechanisms of chemoreceptors. Navchetan, Delhi, pp 156–174Google Scholar
  53. Wasserman K, Van Kessel AL, Burton GG (1967) Interaction of physiological mechanisms during exercise. J Appl Physiol 22: 71–85PubMedGoogle Scholar
  54. Wasserman K, Whipp BJ, Koyal SN, Clearly MG (1975) Effect of carotid body resection on ventilatory and acid-base control during exercise. J Appl Physiol 39: 354–358PubMedGoogle Scholar
  55. Wasserman K, Whipp BJ, Casaburi R, Beaver WL, Brown HV (1977) CO2 flow to the lungs and ventilatory control. In: Dempsey JA, Reed CE (eds) Muscular exercise and the lung. University of Wisconsin Press, Madison, pp 105–135Google Scholar
  56. Weiler-Ravell D, Cooper DM, Whipp BJ, Wasserman K (1982) Effect of posture on the ventilator response at the start of exercise. Fed Proc 41: 1102Google Scholar
  57. Whipp BJ (1981) The control of the exercise hyperpnea. In: Hornbein T (ed) The regulation of breathing. Dekker, New York, pp 1069–1139Google Scholar
  58. Whipp BJ, Davis JA (1979) Peripheral chemoreceptors and exercise hyperpnea. Med Sci Sports 11: 204–212PubMedGoogle Scholar
  59. Whipp BJ, Ward SA (1982) Cardiopulmonary coupling during exercise. J Exp Biol 100: 175–193PubMedGoogle Scholar
  60. Whipp BJ, Wasserman K, Davis JA, Lamarra N, Ward SA (1980) Determinants of O2 and CO2 kinetics during exercise in man. In: Ceretelli P, Whipp BJ (eds) Exercise bioenergetics and gas exchange. Elsevier, Amsterdam, pp 175–185Google Scholar
  61. Winn R, Hildebrant JR, Hildebrant J (1979) Cardiorespiratory responses following isoproterenol injection in rabbits. J Appl Physiol 47: 352–359PubMedGoogle Scholar
  62. Yamamoto WS (1960) Mathematical analysis of the time course of alveolar CO2. J Appl Physiol 15: 215–219PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. J. Whipp
    • 1
  • S. A. Ward
    • 2
  1. 1.Division of Respiratory Physiology and MedicineUCLA School of Medicine, Harbor-UCLA Medical CenterTorranceUSA
  2. 2.Department of AnesthesiologyUCLA School of Medicine, UCLALos AngelesUSA

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