Effects of Hypoxia and Acidosis on Fish Heart Performance

  • H. Gesser
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The vertebrate cells function with few exceptions optimally under aerobic conditions and at pH values within a close range. The heart muscle is frequently taken as an example of a tissue where this is particularly true.


Rainbow Trout Heart Muscle Action Potential Duration Hypercapnic Acidosis Force Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Andreasen P (submitted) Free and total calcium concentrations in blood of rainbow trout, Salmo gairdneri, during “stress” conditionsGoogle Scholar
  2. Bing OHL, Brooks WW, Messer JV (1972) Effects of isoprotorenol on heart muscle performance during myocardial hypoxia. J Mol Cell Cardiol 4: 319–328PubMedCrossRefGoogle Scholar
  3. Damm Hansen H, Gesser H (1980) Relation between non-bicarbonate buffer value and tolerance to cellular acidosis: A comparative study of myocardial tissue. J Exp Biol 84: 161–167Google Scholar
  4. Davidson S, Maroko PR, Braunwald E (1974) Effects of isoprotorenol on contractile function of the ischemic and anoxie heart. Am J Physiol 227: 439–443PubMedGoogle Scholar
  5. Dejours P (1975) Principles of comparative physiology. North-Holland, AmsterdamGoogle Scholar
  6. Ellis D, Thomas RC (1976) Direct measurement of the intracellular pH of mammalian cardiac muscle. J Physiol 262: 755–771PubMedGoogle Scholar
  7. Fabiato A, Fabiato F (1978) Effects of pH on the myofilaments and the sarcoplasmatic reticulum of skinned cells from cardiac and skeletal muscles. J Physiol 276: 233–255PubMedGoogle Scholar
  8. Gesser H (1976) Significance of the extracellular bicarbonate buffer system to anaerobic glycolysis in hypoxic muscle. Acta Physiol Scand 98: 110–115PubMedCrossRefGoogle Scholar
  9. Gesser H (1977) The effects of hypoxia and reoxygenation on force development in myocardia of carp and rainbow trout: Protective effects of C02 /HCCC. J Exp Biol 69: 199–206PubMedGoogle Scholar
  10. Gesser H (1977) The effects of hypoxia and reoxygenation on force development in myocardia of carp and rainbow trout: Protective effects of C02 /HCCC. J Exp Biol 69: 199–206PubMedGoogle Scholar
  11. Gesser H, Poupa O (1974) Relations between heart muscle enzyme pattern and directly measured tolerance to anoxia. Comp Biochem Physiol 48: 97–104CrossRefGoogle Scholar
  12. Gesser H, Poupa O (1975) Lactate as substrate for force development in hearts with différent iso¬enzyme patterns of lactate dehydrogenase. Comp Biochem Physiol 52B: 311–313CrossRefGoogle Scholar
  13. Gesser H, Poupa O (1978) The role of intracellular Ca2+ under hypercapnic acidosis of cardiac muscle: Comparative aspects. J Comp Physiol 127: 307–313Google Scholar
  14. Gesser H, Poupa O (1981) Acidosis and Ca2+ distribution in myocardial tissue of flounder and rat. J Comp Physiol 143: 245–251Google Scholar
  15. Gesser H, Poupa O (1983) Acidosis and cardiac muscle contractility: comparative aspects. Comp Hearse DJ, Chain EB (1972) The role of glucose in the survival and recovery of the anoxie isolated perfused rat heart. Biochem J 128: 1125–1133Google Scholar
  16. Heisler N (1982) Transepithelial ion transfer processes as mechanisms for fish acid-base regulation in hypercapnia and lactacidosis. Can J Zool 60: 1108–1122CrossRefGoogle Scholar
  17. Kammermaier H, Schmidt P, Jûngling E (1982) Free energy change of ATP hydrolysis: a causal factor of early hypoxic failure of the myocardium? J Mol Cell Cardiol 14: 267–277CrossRefGoogle Scholar
  18. Kilarsky W (1967) The fine structure of striated muscles in teleosts. Z Zellforsch 79: 562–580CrossRefGoogle Scholar
  19. La Manna JC, Saive JJ, Snow TR (1980) The relative time course of early changes in mitochondrial function and intracellular pH during hypoxia in the isolated toad ventricle strip. Cire Res 46: 755–763Google Scholar
  20. Matthews PM, Radda GK, Taylor DJ (1981) A 31pnmr study of metabolism in the hypoxic perfused rat heart. Trans Biochem Soc 9: 236–237Google Scholar
  21. McClellan G, Weisberg A, Winegard S (1983) Energy transport from mitochondria to myofibril by a creatine phsophate shuttle in cardiac cells. Am J Physiol 245: C423–C427PubMedGoogle Scholar
  22. McDonald TF, MacLeod DP (1971) Anoxia-recovery cycle in ventricular muscle: Action potential duration contractility and ATP content. Pfliigers Arch 325: 305–322Google Scholar
  23. Meyer RA, Sweeny LH, Kushmerick MJ (1984) A simple analysis of the “phosphocreatine shuttle”. Am J Physiol 246: C365–C377PubMedGoogle Scholar
  24. Niedergerke R, Page S (1977) Analysis of catecholamine effect in single atrial trabeculae of the frog heart. Proc R Soc Lond B Biol Sci 197: 333–362PubMedCrossRefGoogle Scholar
  25. Nielsen KE, Gesser H (1983) Effects of [Ca2+]0 on contractility in the anoxie cardiac muscle of mammal and fish. Life Sci 2: 1437–1442CrossRefGoogle Scholar
  26. Nielsen KE, Gesser H (1984a) Eel and rainbow trout myocardium under anoxia and/or hypercapnic acidosis, with changes in [Ca2+]0 and [Na+]0. Mol Physiol 5: 189–198Google Scholar
  27. Nielsen KE, Gesser H (1984b) Energy metabolism and intracellular pH in trout heart muscle under anoxia and différent [Ca2+]0. J Comp Physiol 154 (5): 523–527Google Scholar
  28. Ostadal B, Schiebler TH (1971) Ûber die terminale Strombahn in Fischherzen. Z Anat Entwick- lungsgesch 134: 101–110CrossRefGoogle Scholar
  29. Pette D (1965) Plan und Muster im zellulâren Stoffwechsel. Naturwissenschaften 52: 557–616CrossRefGoogle Scholar
  30. Poupa O, Gesser H, Jonsson S, Sullivan L (1974) Coronary-supplied compact shell of ventricular myocardium in Salmonids. Growth and enzyme pattern. Comp Biochem Physiol 48A: 85–95Google Scholar
  31. Randall D (1984) In: Johansen K, Burggren W (eds) Shunts in fish gills. Alfred Benzon Symposium 21, Munksgaard (in press)Google Scholar
  32. Roos A (1975) Intracellular pH and distribution of weak acids across the cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm. J Physiol (Lond) 249: 1–26Google Scholar
  33. Ruben JA, Bennett AF (1981) Intense exercise, bone structure and blood calcium levels in verte¬brates. Nature 291: 411–413PubMedCrossRefGoogle Scholar
  34. Saks VA, Rosenshtrauk LV, Smirnow VN, Chazov El (1978) Role of creatine phosphokinase in cellular function and metabolism. Can J Physiol Pharmacol 56: 691–706PubMedCrossRefGoogle Scholar
  35. Santer RM, Walker MG (1980) Morphological studies of the ventricle of teleost and elasmobranch hearts. J Zool (Lond) 190: 259–272CrossRefGoogle Scholar
  36. Strome RD, Clancy RL, Gonzales NC (1976) Myocardial C02 buffering: Role of transmembrane transport of H+ or HCO3 ions. Am J Physiol 230: 1037–1041PubMedGoogle Scholar
  37. Williamson JR (1964) Metabolic effects of epinephrine in the isolated perfused rat heart. J Biol Chem 239: 2721–2729PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Gesser
    • 1
  1. 1.Department of ZoophysiologyUniversity of AarhusAarhus CDenmark

Personalised recommendations