Abstract
Differentiation is generally conceived to be a program of gene expression, primarily determined by regulation of transeriptional processes. In some cell types, however, including those constituting the erythron, one can distinguish a subprogram which involves practically exclusively posttranscriptional e vents. This phase of differentiation may be designated as maturation. During the differentiation of the erythron the activity of the nucleus ceases after the stage of the basophilic erythroblast. There ensues pyknosis of the nucleus with cessation of new formation and export of ribonucleic acids. The pyknotic nucleus of the late erythroblast (normoblast) is expelled in the mammalia, but is retained in an inactive form in all other vertebrates. The transition from the basophilic erythroblast to the normoblast defines clearly the end of the transscriptional phase of differentiation and the beginning of its maturational phase.
Keywords
- Cytochrome Oxidase
- Cytochrome Oxidase Activity
- Methionine Sulfoxide
- Normal Steady State
- Active Transport Amino Acid
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Augustin HW, Rapoport S (1959) Über Atmung und Succinatoxydasesystem bei reifen und jugendlichen Hühnererythrozyten. Acta Biol Med Ger 3:433–449
Dubiel W, Müller M, Rapoport S (1981) ATP-dependent proteolysis of reticulocyte mitochondria is preceded by the attack of lipoxygenase. Biochem Int 3: 165–171
Fritsch B, Maretzki D, Hiebsch CH, Schewe T, Rapoport S (1979) Zur Selektivität der Wirkung der Lipoxygenase aus Kaninchenretikulozyten auf Mitochondrien- und Erythrozytenmembra- nen. Acta Biol Med Ger 38: 1315–1321
Kühn H, Wiesner R, Schewe T, Rapoport SM (1983) Reticulocyte lipoxygenase exhibits both n-6 and n-9 activities. FEBS Lett 153: 353–356
Müller M, Dubiel W, Rathmann J, Rapoport S (1980) Determination and characteristics of energy dependent protolysis in rabbit retieulocytes. Eur J Biochem 109: 405–410
Rapoport SM, Rosenthal S, Schewe T, Sehultze M, Müller M (1974) The metabolism of the reticulocyte. In: Yoshikawa H, Rapoport SM (eds) Cellular and molecular biology of erythrocytes. University of Tokyo Press, Tokyo, p 93
Rapoport SM, Schewe T, Wiesner R, Halangk W, Ludwig P, Janicke-Höhne M, Tannert CH, Hiebsch CH, Klatt D (1979) The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte. Eur J Biochem 96: 545–561
Rapoport S, Müller M, Dumdey R, Rathmann J (1980) Nitrogen economy and the metabolism of serine and glycine in reticulocytes of rabbits. Eur J Biochem 108: 449–455
Rapoport S, Dubiel W, Müller M (1982) Characteristics of an ATP-dependent proteolytic system of rat liver mitochondria. FEBS Lett 147: 93–96
Rapoport S, Dubiel W, Müller M (1983) Calcium exerts an indirect effect on ATP-dependent pro- teolysis of rat liver mitochondria. FEBS Lett 160: 134–136
Rapoport S, Härtel B, Hausdorf G (1984) Methionine sulfoxide formation — the cause of self-in- activation of reticulocyte lipoxygenase. Eur J Biochem 139: 573–576
Richter-Rapoport SKN, Dumdey R, Hiebsch CH, Thamm R, Uerlings I, Rapoport S (1977) Charakterisierang von Retikulozyten des Menschen: Atmung, Pasteur-Effekt und elektronenmikroskopische Befunde an Mitochondrien. Acta Biol Med Ger 36: 53–64
Salzmann U, Kühn H, Schewe T, Rapoport SM (1984) Pentane formation during the anaerobic reactions of reticulocyte lipoxygenase. Comparison with lipoxygenasesfrom soybeans and green pea seeds. Biochem Bioph Acta 795: 535–542
Salzmann U, Ludwig P, Schewe T, Rapoport SM (1985) The share of lipoxygenase in the antimycin-resistant oxygen uptake of intact rabbit reticulocytes. Biomed Biochim Acta 44: 213–221
Schewe P, Halangk W, Hiebsch CH, Rapoport SM (1975) A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria. FEBS Lett 60: 1
Schewe T, Albracht SPJ, Ludwig P (1981b) On the site of action of the inhibition of the mitochondrial respiratory chain by lipoxygenase. Biochim Biophys Acta 636: 210
Siems W, Müller M, Dumdey R, Holzhütter HG, Rathmann J, Rapoport SM (1982) Quantification of pathways of glucose utilization and balance of energy metabolism of rabbit reticulocytes. Eur J Biochem 124: 567–576
Siems W, Dubiel W, Dumdey R, Müller M, Rapoport SM (1984) Accounting for the ATP-consuming processes in rabbit reticulocytes. Eur J Biochem 139: 101–107
Thiele BJ, Belkner J, Andree H, Rapoport TA, Rapoport SM (1979) Synthesis of a lipoxygenase in reticulocytes. Synthesis of non-globin-proteins in rabbit erythroid cells. Eur J Biochem 96: 563–569
Thiele BJ, Andree H, Höhne M, Rapoport SM (1982) Translations repression of lipoxygenase mRNA in reticulocytes. Eur J Biochem 129: 133–141
Wiesner R, Rosenthal S, Hiebsch CH (1973) Leitkriterien der Retikulozytenreifung. II. Das Verhalten von Zytochromoxydase und Hemmstoff F der Atmungskette bei der Retikulozytenreifung. Acta Biol Med Ger 30: 631–646
Wiesner R, Schewe T, Ludwig P, Rapoport SM (1981) Reversibility of the inhibition of the cytochrome c oxidase by reticulocyte lipoxygenase. FEBS Lett 123:123
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rapoport, S.M. (1985). Mechanisms of the Maturation of the Reticulocyte. In: Gilles, R. (eds) Circulation, Respiration, and Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70610-3_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-70610-3_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70612-7
Online ISBN: 978-3-642-70610-3
eBook Packages: Springer Book Archive