Skip to main content

Endocrine Ophthalmopathy

  • Conference paper
Ciclosporin in Autoimmune Diseases

Abstract

Endocrine ophthalmopathy is one of a triad of features including hyperthyroidism and pretibial dermopathy which characterize Graves’ (Parry’s, Basedow’s) disease [4–6, 13]. The ophthalmopathy occurs in clinically recognizable form in about half of the patients with the hyperthyroidism of Graves’ disease, is severe in perhaps 3–5%, and may be present in an occult form in many (but not all) of the remainder of the patients with Graves’ disease. Conversely, it may occur in the absence of hyperthyroidism, and in many of these patients there is evidence of either overt or occult autoimmune thyroiditis. In still another small group with the same type of oculopathy, no evidence whatever of any thyroid disturbance is revealed by even the most sophisticated testing [15].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blau HN, Kaplan I, Tao GW, Kriss, JP (1983) Thyroglobulin-independent cell mediated cytotoxicity of human eye muscle cells in tissue culture by lymphocytes of a patient with Graves’ ophthalmopathy. Life Sci 32:54

    Article  Google Scholar 

  2. Faryna M, Naumann J, Gardas A (1985) Measurement of autoantibodies against human eye muscle plasma membranes in Graves’ ophthalmopathy. Br Med J 290:191

    Article  CAS  Google Scholar 

  3. Gamblin GT, Harper DG, Galentine P, Buck DR, Chernow B, Eil C (1983) Prevalence of increased intra-ocular pressure in Graves’ disease:Evidence of frequent subclinical ophthalmopathy. N Engl J Med 308:420

    Article  PubMed  CAS  Google Scholar 

  4. Gorman CA (1983) Ophthalmopathy of Graves’ disease. N Engl J Med 308:453

    Article  PubMed  CAS  Google Scholar 

  5. Gorman CA, Waller RR, Dyer JA (1984) The eye and orbit in thyroid disease. Raven Press, New York, pp 1–341

    Google Scholar 

  6. Jacobson DH, Gorman CA (1984) Endocrine ophthalmopathy:Current ideas concerning etiology, pathogenesis and treatment. Endocr Rev 5:200–220

    Article  PubMed  CAS  Google Scholar 

  7. Kendall-Taylor P, Atkinson S, Holcombe M (1984) A specific IgG in Graves’ ophthalmopathy and its relation to reto-orbital and thyroid autoimmunity. Br Med J 288:1183

    Article  CAS  Google Scholar 

  8. Kodama K, Sikorska H, Bandy-Dafoe P, Bayly R, Wall JR (1982) Demonstration of a circulations autoantibody against a soluble eye muscle antigen in Graves’ ophthalmopathy. Lancet 2:1353

    Article  PubMed  CAS  Google Scholar 

  9. Kodama K, Sikorska H, Bayly R, BandyDafoe P, Wall JR (1984) Use of monoclonal antibodies to detect a possible role for thyroglobulin in the pathogenesis of Graves’ ophthalmopathy. J Clin Endocrinol Metab 59:67

    Article  PubMed  CAS  Google Scholar 

  10. Kohn LD, Winand RJ (1971) Relationship of thyrotropin to exophthalmos-producing substance. Formation of an exophthalmos producing substance by pepsin digestion of pituitary glycoprotein containing both thyrotropic and exophthalmogenic activity. J Biol Chem 246:6570

    Google Scholar 

  11. Kriss JP (1970) Radio isotopic thyroidolymphography in patients with Graves’ disease. J Clin Endocrinol Metab 31:315

    Article  PubMed  CAS  Google Scholar 

  12. Kriss JP, Mehdi SO (1979) Cell mediated lysis of lipid vessicles containing eye muscle protein. Implications regarding pathogenesis of Graves’ ophthalmopathy. Proc Natl Acad Sci USA 76:2003

    Google Scholar 

  13. Lewis M, Topliss DJ, Okita N, How J, Row VV, Volpe R (1983) The etiology of endocrine exophthalmos. In: Franklin EC (ed) Clinical Immunology Update 1983. Elsevier Biomedical, New York, pp 261–280

    Google Scholar 

  14. Munro RE, Lamki L, Row VV, Volpe R (1973) Cell mediated immunity in the exophthalmos of Graves’ disease as demonstrated by the migration inhibition factor ( MIF) test. J Clin Endocrinol Metab 37:286

    Article  PubMed  CAS  Google Scholar 

  15. Volpe R (1985) Autoimmune thyroid disease. In: Volpe R (ed) Autoimmunity and endocrine diseases. Marcel Dekker New York, pp 225–231

    Google Scholar 

  16. Werner SC (1977) Modification of the classification of the eye changes of Graves’ disease. Recommendation of the ad hoc Committee of the American Thyroid Association (Editorial). J Clin Endocrinol Metab 44:203

    Article  PubMed  CAS  Google Scholar 

  17. Werner SC (1978) Eye changes. In: Werner SC, Ingbar SH (eds) The thyroid, a fundamental and clinical text, edn 4. Harper and Row, Hagerstown, Maryland, pp 655

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Sandoz Ltd, Basle

About this paper

Cite this paper

Volpé, R. (1985). Endocrine Ophthalmopathy. In: Schindler, R. (eds) Ciclosporin in Autoimmune Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70607-3_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70607-3_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70609-7

  • Online ISBN: 978-3-642-70607-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics