Skip to main content
SpringerLink
Log in

Ciclosporin (CyA) in Myasthenia Gravis

  • Conference paper
Ciclosporin in Autoimmune Diseases

Abstract

Myasthenia gravis (MG) is a humorally mediated autoimmune disease. Circulating autoantibodies (ab) against the postsynaptic acetylcholine receptor (ACHR) are responsible for the postsynaptic transmission failure which is the cause of the abnormal weakness and fatigability of the skeletal muscles in myasthenics [16].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Besinger UA, Toyka KV, Fateh-Moghadam A, et al. (1980) Die Bedeutung eines quantitativen klinischen Bewertungssystems fir die Verlaufsbeobachtung der Myasthenia gravis:eine prospektive Studie. In:Mertens HG, Przuntek H (eds) Pathologische Erregbarkeit des Nervensystems. Springer, Berlin, pp 568–572

    Google Scholar 

  2. Besinger UA, Toyka KV, Heininger K, et al. (1981) Long term correlation of clinical course and acetylcholine receptor antibody in patients with myasthenia gravis. Ann NY Acad Sci 377:812–815

    Article  Google Scholar 

  3. Besinger UA, Toyka KV, Hömberg M, Heininger K, Hohlfeld R, Fateh-Moghadam A (1983) Myasthenia gravis:long-term correlation of binding and bungarotoxin blocking antibodies against acetylcholine-receptors with changes in disease severity. Neurology 33:1316–1321

    PubMed  CAS  Google Scholar 

  4. Beveridge T, Krupp P, McKibbiu C (1984) Lymphomas and lymphoproliferative lesions developing and cyclosporin therapy. Lancet No. 8380, Vol I:788

    Google Scholar 

  5. Borel JF, Wiesinger D (1977) Effects of cyclosporin A on murine lymphoid cells. In:Lucas DO (ed) Regulatory mechanisms in lymphocyte activation. Academic Press, New York, p 716

    Google Scholar 

  6. Borel JF, Lafferty KJ (1983) Cyclosporine:Speculation about its mechanisms. Transplant Proc 15:1881–1885

    Google Scholar 

  7. Bouwer HGA, Hinrichs DJ (1983) Cyclosporine effects on mitogen induced T- and B-cell proliferation. Transplant Proc XVII, Suppl 1:2306–2310

    Google Scholar 

  8. van Buren CT, Kerman R, Rechner S, Kahan BD (1983) Cyclosporine effects on immunoregulatory cells in men. Transplant Proc 15:2293–2297

    Google Scholar 

  9. Dau PC (1981) Plasmapheresis and immunosuppressive drug therapy in sixty myasthenia gravis patients. Ann NY Acad Sci:700–708

    Google Scholar 

  10. Donatsch P, Abisch E, Homberger M, et al. (1981) A radioimmunoassay to measure cyclosporin A in plasma and serum samples. J Immunoassay 2:19–32

    Article  PubMed  CAS  Google Scholar 

  11. Mraz W, Zink RA, Graf A, Preis D, Illner WD, Land W, Siebert W, Zöttlein H (1983) Distribution and transfer of cyclosporine among the various human lipoprotein classes. Transplant Prov 15:2426–2429

    Google Scholar 

  12. Mraz W, unpublished

    Google Scholar 

  13. Mertens HG, Hertel G, Reuther P, Ricker K (1981) Effect of immunosuppressive drugs (Azathioprine). Ann NY Acad Sci:691–699

    Google Scholar 

  14. Myers BD, Ross J, Newton L, Luetscher J, Perlroth M (1984) Cyclosporine-associated chronic nephrotoxicity. N Engl J Med 311:699–705

    Article  PubMed  CAS  Google Scholar 

  15. Stiller CR, Dupré J, Gent M, Jenner MR, Klown PA, Lampacis A, Martell R, Rodger NW, v. Graffenried B, Wolfe BMI (1984) Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223:1362–1366

    Article  PubMed  CAS  Google Scholar 

  16. Thiru S, Calne RY, Nagington J (1981) Lymphoma in renal allograft patients treated with cyclosporin as one of the immunosuppressive agents. Transplant Proc 13:359

    PubMed  CAS  Google Scholar 

  17. Toyka KV, Drachman DB, Griffin DE, et al. (1977) Myasthenia gravis:study of humoral immune mechanisms by passive transfer to mice. N Engl J Med 296:125–131

    Article  PubMed  CAS  Google Scholar 

  18. Toyka KV, Becker T, Fateh-Moghadam A, Besinger UA (1979) Die Bedeutung der Bestimmung von Antikörpern gegen Acetylcholinrezeptoren in der Diagnostik der Myasthenia gravis. Klin Wochenschr 57:937–942

    Article  PubMed  CAS  Google Scholar 

  19. Wekerle A, Hohlfeld R, Ketelsen UP, Kalden JR, Kalies J (1981) Thymic myogenesis, T-lymphocytes and the pathogenesis of myasthenia gravis. Ann NY Acad Sci:455 —476

    Google Scholar 

  20. Wenk E, Follath F, Abisch E (1983) Temperatur dependency of apparent cyclosporin A concentration in plasma. Clin Chem 29:1865

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Klinik, Technischen Universität München, Möhlstraße 28, D-8000, München 80, Germany

    U. A. Besinger

  2. Abteilung Klinische Chemie am Klinikum Großhadem, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-8000, München 70, Germany

    W. Mraz & A. Fateh-Moghadam

Authors
  1. U. A. Besinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Mraz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Fateh-Moghadam
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pharmaceutical Department MPP / PAI, Journals and Monographs, Sandoz Ltd, CH-4002, Basle, Switzerland

    Rosemarie Schindler

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Sandoz Ltd, Basle

About this paper

Cite this paper

Besinger, U.A., Mraz, W., Fateh-Moghadam, A. (1985). Ciclosporin (CyA) in Myasthenia Gravis. In: Schindler, R. (eds) Ciclosporin in Autoimmune Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70607-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70607-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70609-7

  • Online ISBN: 978-3-642-70607-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation