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Ciclosporin in the Treatment of Myasthenia Gravis: Preliminary Results from a Pilot Study

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Ciclosporin in Autoimmune Diseases

Abstract

Aquired myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission. It is characterized by variable weakness and fatigability of skeletal muscle due to interference with neuromuscular transmission by antibodies to acetylcholine receptors (AChR). Circulating polyclonal anti-AChR antibodies can be demonstrated in nearly 90% of patients with generalized MG [5].

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References

  1. Borel JF, von Graffenried B (in press) Sandimmun (Cyclosporin A) and autoimmunity. In: Proceedings of the Workshop on recent advances in systemic lupus erythematosus, Geneva, Switzerland, 1–3 September 1983, Academic Press, London

    Google Scholar 

  2. Drachman DB (1981) The biology of myasthenia gravis. Annu Rev Neurosci 4:195–225

    Article  PubMed  CAS  Google Scholar 

  3. Engel AG (1984) Myasthenia gravis and myasthenic syndromes. Ann Neurol 16:519 –534

    Article  PubMed  CAS  Google Scholar 

  4. Lefvert AK, Bergström K, Matell G, Osterman PO, Pirskanen R (1978) Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenic implications. J Neurol Neurosurg Psychiatry 41:394–403

    Article  PubMed  CAS  Google Scholar 

  5. Lindström J, Seybold ME, Lennon VA et al. (1976) Antibody to acetylcholine receptor in myasthenia gravis. Neurology (Minneap.) 26:1054–1059

    Google Scholar 

  6. Mertens HG, Hertel G, Reuther P et al. (1981) Effect of immunosuppressive drugs (azathioprine). Ann NY Acad Sci 377:691–699

    Article  PubMed  CAS  Google Scholar 

  7. Muraguchi A, Butler JL, Kehrl JH, Falkoff RJM, Fauci AS (1983) Selective suppression of an early step in human B cell activation by cyclosporin A. J Exp Med 158:690–702

    Article  PubMed  CAS  Google Scholar 

  8. Olanow CW, Lane RJ, Roses AD (1981) Relationship between the acetylcholine receptor antibody titer and the clinical status in myasthenia gravis. Ann NY Acad Sci 377:856–857

    Article  Google Scholar 

  9. Oosterhuis HJGH, Limburg PC, HummelTappel E et al. (1983) Anti-acetylcholine receptors in myasthenia gravis. II. Clinical and serological follow-up of individual patients. J Neurol Sci 58:371–385

    Article  PubMed  CAS  Google Scholar 

  10. Tindall RSA (1981) Humoral immunity in myasthenia gravis: biochemical characterization of acquired antireceptor antibodies and clinical correlations. Ann Neurol 10:437–447

    Article  PubMed  CAS  Google Scholar 

  11. Vincent A, Newsom-Davis J (1980) Anti-acetylcholine receptor antibodies. J Neurol Neurosurg Psychiatry 43:590–600

    Article  PubMed  CAS  Google Scholar 

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© 1985 Sandoz Ltd, Basle

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Nyberg-Hansen, R., Gjerstad, L. (1985). Ciclosporin in the Treatment of Myasthenia Gravis: Preliminary Results from a Pilot Study. In: Schindler, R. (eds) Ciclosporin in Autoimmune Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70607-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-70607-3_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70609-7

  • Online ISBN: 978-3-642-70607-3

  • eBook Packages: Springer Book Archive

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