Effects of Arachidonic Acid on Blood-Brain Barrier Function
Increased concentrations of free fatty acids, especially arachidonic acid (AA), have been found in brain tissue under several conditions, such as ischemia (9), severe hypoxia (5) or hypoglycemia (1), cold injury (4), and seizures (8). In addition, release of AA into edema fluid sampled from perifocal brain areas surrounding a cold lesion has been detected (7). AA or its products obviously influence membrane function of parenchymal cells since they may induce cytotoxic edema (3). Electron microscopic investigations have shown lesions of endothelial cells of cerebral vessels exposed to AA (6). Therefore, AA and its metabolites may act as mediators of secondary brain damage, i.e., vasogenic edema. It was the aim of the present study to investigate the effects of AA on the blood-brain barrier (BBB) and the caliber of extraparenchymal cerebral arteries and veins when superfusing the cortical surface.
KeywordsPermeability Ischemia Attenuation Prostaglandin Paraffin
Unable to display preview. Download preview PDF.
- 4.Chan, P.H., Fishman, R.A.: Phospholipid degradation and the early release of polyunsaturated fatty acids in the evolution of brain edema. In: Go, K.G., Baethmann, A. (eds.) Recent progress in the study and therapy of brain edema, pp. 193–202. Plenum Press, New York 1984Google Scholar
- 7.Maier-Hauff, K., Lange, M., Schürer, L., Guggenbichler, C., Vogt, W., Jacob, K., Baethmann, A.: Glutamate and free fatty acid concentrations in extracellular vasogenic edema fluid. In: Go, K.G., Baethmann, A. (eds.) Recent progress in the study and therapy of brain edema, pp. 183–192. Plenum Press, New York 1984Google Scholar