A Role for Poly(ADP-Ribose) in Radiogenic and Chemically-Induced Malignant Transformation and Mutagenesis

  • Carmia Borek
  • Augustinus Ong
  • Xi-Cang Guo
  • James E. Cleaver
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


3-aminobenzamide (3AB) is a nicotinamide analog which was first introduced as an inhibitor of poly(ADP-ribose) synthesis [29]. 3AB has a multitude of effects on cells previously exposed to DNA damaging agents, which have been taken to indicate a role for poly(ADP-ribose) synthesis in DNA repair [1–3, 9, 10, 12, 13, 15–17, 22–27, 31–33]. Other side effects suggest, however, that 3AB may not be as specific as supposed [9, 10, 14, 18, 21]. 3AB also inhibits malignant transformation by radiation and methylating agents in human, mouse, and hamster cells [5–7, 19]. We have now compared the effects of low concentrations of 3AB on mutagenesis and transformation, in view of the supposed similarities in these processes.


Chinese Hamster Ovary Cell Sister Chromatid Exchange Methyl Methane Sulfonate Syrian Hamster Embryo Normal Human Lymphocyte 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Carmia Borek
    • 1
  • Augustinus Ong
    • 1
  • Xi-Cang Guo
    • 2
    • 3
  • James E. Cleaver
    • 2
  1. 1.Department of Radiology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Laboratory of Radiobiology and Environmental HealthUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of Radiological MedicineSuzhou Medical CollegeSuzhouPeople’s Republic of China

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