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5′-ADP-3″Deoxypentos-2″-Ulose. A Novel Product of ADP-Ribosyl Protein Lyase

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Book cover ADP-Ribosylation of Proteins

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Our previous studies [1, 2] revealed that the degradation of poly(ADP-ribosyl) proteins is carried out by consecutive actions of two enzymes, poly(ADP-ribose) glycohydrolase [3, 4] and ADP-ribosyl protein lyase (formerly termed ADP-ribosyl histone splitting enzyme) [5] (Fig. 1). The latter enzyme catalyzes removal of the last proximal ADP-ribosyl residue from acceptor protein. This report presents, after a brief review of ADP-ribosyl histones and the lyase, the identification of the enzymatic split product as a novel sugar derivative, and discusses its significance in poly(ADP-ribosyl) protein metabolism.

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Abbreviations

FT-IR:

Fourier Transformed Infrared Spectrogram

GC/MS:

Gas Chromatography/Mass Spectrometry

HPLC:

High Performance Liquid Chromatography

References

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Author information

Authors and Affiliations

  1. Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606, Japan

    Kunihiro Ueda

  2. Osaka Medical College, Takatsuki, Osaka 569, Japan

    Osamu Hayaishi

  3. The National Institute of Nutrition, Shinjuku-ku, Tokyo 162, Japan

    Jun Oka

  4. Suntory Institute for Bioorganic Research, Shimamoto-cho, Mishima-gun, Osaka 618, Japan

    Hajime Komura & Koji Nakanishi

Authors
  1. Kunihiro Ueda
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  2. Osamu Hayaishi
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  3. Jun Oka
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  4. Hajime Komura
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  5. Koji Nakanishi
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Editor information

Editors and Affiliations

  1. Institut für Pharmakologie und Biochemie, Veterinärmedizinische Fakultät der Universität, CH-8057, Zürich, Switzerland

    Felix R. Althaus

  2. Physiologisch-chemisches Institut, Universität Hamburg, 2000, Hamburg 20-40, Germany

    Helmuth Hilz

  3. The University of Sussex, Biology Building, Brighton, Sussex, BN1 9QG, England

    Sydney Shall

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© 1985 Springer-Verlag Berlin Heidelberg

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Ueda, K., Hayaishi, O., Oka, J., Komura, H., Nakanishi, K. (1985). 5′-ADP-3″Deoxypentos-2″-Ulose. A Novel Product of ADP-Ribosyl Protein Lyase. In: Althaus, F.R., Hilz, H., Shall, S. (eds) ADP-Ribosylation of Proteins. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70589-2_22

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  • DOI: https://doi.org/10.1007/978-3-642-70589-2_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70591-5

  • Online ISBN: 978-3-642-70589-2

  • eBook Packages: Springer Book Archive

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