Effect of DNA Intercalators on Poly(ADP-Ribose) Glycohydrolase Activity

  • Manoochehr Tavassoli
  • Sydney Shall
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Poly(ADP-ribose) glycohydrolase is the major enzyme responsible for the degradation of poly(ADP-ribose) [1, 2]. This enzyme hydrolyses the ribosyl-ribose bond between the two ADP-ribose units and produces ADP-ribose. We have purified this enzyme to near homogeneity and characterised its properties [2].


Ethidium Bromide Phosphodiesterase Activity Cancer Research Campaign Snake Venom Phosphodiesterase Histone Complex 
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2-thoxy-6,9 acridine diamine


4′-(9-acridinylamino) methanesulphon-m-anisidide

Tilorone R10,556 DA



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  1. 1.
    Miyakawa N, Ueda K, Hayaishi O (1972) Association of poly(ADP-ribose) glycohydrolase with liver chromatin. Biochem Biophys Acta Res Commmun 49:239–245CrossRefGoogle Scholar
  2. 2.
    Tavassoli M, Tavassoli MH, Shall S (1983) Isolation and purification of poly(ADP-ribose) glycohydrolase from pig thymus. Eur J Biochem 135:449–455PubMedCrossRefGoogle Scholar
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    Farzaneh F, Zalin R, Brill D, Shall S (1982) DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation. Nature (London) 300:362–366CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Manoochehr Tavassoli
    • 1
  • Sydney Shall
    • 1
  1. 1.Cell and Molecular Biology LaboratoryUniversity of SussexBrighton, East SussexGreat Britain

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