Genetic Analysis of Bacterial Virulence Determinants in Bordetella pertussis and the Pathogenic Yersinia
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With the advent of recombinant DNA technology, rapid advances have been made in understanding the molecular organization of bacterial pathogens (for review, see Macrina 1984). This has been especially true in the analysis of enterotoxin structure and function (So et al. 1976, 1978; MOSELEYand FALKOW1980; PEARSONand MEKALANOS1982) as well as in the evaluation of bacterial pili and hemolysins in gastrointestinal or extraintestinal infections (SVANBORG-EDEN and HANSSON 1978; WELCH etal. 1981; HARTLEINetal. 1983). Similarly, such studies have clarified the role of iron uptake in the infectious process (CROSA1984) and have been helpful in understanding better the molecular epidemiology of disease agents (HULLet al. 1984). We suppose that in the near future most virulence factors defined by classic studies in medical microbiology will be analyzed at the genetic level in some manner or other.
KeywordsPertussis Toxin Yersinia Enterocolitica Bordetella Pertussis Pertussis Infection Enterotoxin Gene
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