Abstract
Blood and urine cadmium and urine ß 2-microglobulin concentrations were determined in a group of 28 factory workers who had been exposed to differing intensities of cadmium fume for between 0.5 and 35 years (mean 15 years S.D. 10). Repeated measurements were carried out over a two-year period, both before and following the cessation of all exposure. There were found to be clear associations between both the intensity and duration of exposure and the various biological measures used to assess the exposure. Following the cessation of exposure, there was no significant change in blood and urine cadmium concentrations some 18 months later. A “critical” concentration of cadmium in urine appeared to be 10 µg/g creatinine.
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References
Friberg L, Kjellström T, Nordberg GF (1986) Cadmium; in: Handbook on the Toxicology of Metals - 2nd edn. vol II: Specific Metals. Friberg L, Nordberg GF, Vouk V (eds) Elsevier Science Publishers, Amsterdam, pp 130 - 184
Friberg L, Piscator M, Nordberg GF, Kjellström T (1974) Cadmium in the Environment - 2nd edn. CRC Press, Cleveland, Ohio, USA
Gompertz D, Fletcher JG, Perkins J, Smith NJ, Chettle DR, Mason H, Scott MC, Topping MD, Blindt M (1983) Renal Dysfunction in Cadmium Smelters: relation to in-vivo liver and kidney cadmium concentrations. Lancet 7: 1185 - 1187
Friberg L (1950) Health Hazards in the Manufacture of Alkaline Accumulators with Special Reference to Chronic Cadmium Poisoning. Acta. Med. Scand. Suppl. 240: 1 - 124
Nriagu JO (ed) (1981) Cadmium in the Environment - Part 2 Health Effects. J. Wiley, In- terscience, New York
Kjellström T, Evrin P-E, Rahnster B (1977) Dose-Response Analysis of Cadmium-induced Tubular Proteinuria. Environmental Research, 73: 303 - 317
Bernard A, Buchet JP, Roels H, Masson P, Lauwerys R (1979) Renal Excretion of Protein and Enzymes in Workers Exposed to Cadmium. Eur. J. Clin. Invest. 9: 11-22
Lauwerys RL, Roels HA, Buchet J-P, Bernard A, Stanescu D (1979) Investigation on the Lung and Kidney Functions in Workers Exposed to Cadmium. Environmental Health Per-spectives 28: 137 - 145
Herber RFM (1984) Beta-2 Microglobulin and Other Urinary Proteins as an Index of Cadmium Nephrotoxicity. Pure & Appl. Chem. 56: 957 - 965
Scott R, Cunningham C, McLelland A, Fell GS, Fitzgerald-Finch OP, McKellar N (1982) The Importance of Cadmium as a Factor in Calcified Upper Urinary Tract Stone Disease - a prospective 7 year study. Brit. J. Urol. 54: 584-589
Bernard A, Lauwerys R (1984) Cadmium in Human Populations. Experientia 40: 143 - 152
Elinder CG, Edling C, Lindberg E, Agedal BK, Vesterberg O (1985) Assessment of Renal Function in Workers Previously Exposed to Cadmium. Brit. J. Ind. Med. 42: 154-160
Armstrong BG, Kazantzis G (1983) The Mortality of Cadmium Workers. Lancet i:1425- 1427
Alessio L, Odone P, Bertelli G, Foa V (1983) in: Industrial Health and Safety - Human Bi-ological Monitoring of Industrial Chemicals Series. Alessio L, Berlin A, Roi R, Boni M (eds) Commission of the European Communities (EUR 8476 EN), pp 25-44
Hassler E, Lind B, Piscator M (1983) Cadmium in Blood and Urine Related to Present and Past Exposure. A study of workers in an alkaline battery factory. British J. Ind. Med. 40: 420-425
Lauwerys R, Roels H, Regniers M, Buchet J-P, Bernard A, Goret A (1979) Significance of Cadmium Concentration in Blood and Urine in Workers Exposed to Cadmium. Environ-mental Research 20: 375 - 391
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© 1988 Springer-Verlag Berlin Heidelberg
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Braithwaite, R.A., Cowtan, P.R. (1988). Biological Monitoring of Occupational Exposure to Cadmium Fume. In: Stoeppler, M., Piscator, M. (eds) Cadmium. Environmental Toxin Series, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70553-3_6
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DOI: https://doi.org/10.1007/978-3-642-70553-3_6
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