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The Biology of Trypanosomes pp 93–118Cite as

Regulation of Parasitaemia in Mice Infected with Trypanosoma brucei

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 117)

Abstract

Salivarian trypanosomes are spindle-shaped Protozoa belonging to the class Zoomastigophorea, order Kinetoplastida and genus Trypanosoma (Hoare 1970). The parasites are the causative agents of human sleeping sickness (T. brucei) and of trypanosomiases (nagana) affecting domestic animals (T. vivax, T. congolense, T. simiae, T. brucei, T. suis). Salivarian trypanosomes are generally transmitted from mammal to mammal by tsetse flies (Glossina), and their distribution coincides with that of their vector. Tsetse flies are distributed throughout East, Central and West Africa over an area embracing 38 countries and covering approximately 10 million km2. Several control measures have been tried for trypanosomiasis, including eradication of tsetse fly habitats, eradication of tsetse flies, eradication of the reservoir hosts of trypanosomes (wild animals), chemoprophylaxis and/or diagnosis followed by chemotherapy. For a variety of social, political and practical reasons, none of these control measures has met with lasting success (Duggan 1970). Attempts to develop a vaccine against the parasites have been unsuccessful to date owing to extensive parasite antigenic diversity.

Keywords

  • Parasite Population
  • Trypanosoma Brucei
  • Parasite Differentiation
  • Tail Blood
  • Form Parasite

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. ILRAD, P.O. Box 30709, Nairobi, Kenya

    S. J. Black, C. N. Sendashonga, C. O’Brien, N. K. Borowy, M. Naessens, P. Webster & M. Murray

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  1. S. J. Black
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  2. C. N. Sendashonga
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  3. C. O’Brien
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  4. N. K. Borowy
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  5. M. Naessens
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  6. P. Webster
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  7. M. Murray
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  1. Department of Immunology, St. George’s Hospital Medical School, Cranmer Terrace, SW17 ORE, London, Great Britain

    Professor Dr. Leslie Hudson

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Black, S.J. et al. (1985). Regulation of Parasitaemia in Mice Infected with Trypanosoma brucei . In: Hudson, L. (eds) The Biology of Trypanosomes. Current Topics in Microbiology and Immunology, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70538-0_5

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