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Temperature Dependence of the Cardiac Na+ — K+ Pump as Studied by Na-Sensitive Microelectrodes

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Ion Measurements in Physiology and Medicine

Abstract

The energy required for the transport of Na ions from animal cells is provided by the hydrolysis of ATP. Thus, the Na pump is directly coupled to a metabolic process and is expected to be markedly temperature dependent. Hitherto, the temperature dependence of active Na efflux from cardiac Purkinje fibers has not been studied in detail. Eisner and Lederer [1] studied the effect of various temperatures on a transient outward current which is observed following activation of the Na pump in voltage clamped Purkinje fibers. However, the underlying changes in the intracellular Na activity a iNa were not directly recorded. We report here on simultaneous measurements of intracellular Na activity and membrane current in voltage clamped sheep Purkinje fibers during enhanced Na pumping at various temperatures.

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References

  1. Eisner DA, Lederer WJ (1980) Characterization of the electrogenic sodium pump in cardiac Purkinje fibres. J Physiol (Lond) 303: 441–474

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  2. Eisner DA, Lederer WJ, Vaughan-Jones RD (1981) The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres. J Physiol (Lond) 317:163–187

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  3. Gadsby DC (1980) Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers. Proc Natl Acad Sci USA 77: 4035–4039

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  4. Glitsch HG (1982) Electrogenic Na pumping in the heart. Annu Rev Physiol44: 389–400

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  5. Glitsch HG, Pusch H, Schumacher Th, Verdonck F (1982) An identification of the K activated Na pump current in sheep Purkinje fibres. Pflugers Arch 394: 256–263

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Authors
  1. H. G. Glitsch
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  2. H. Pusch
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  3. Th. Schumacher
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Editor information

Editors and Affiliations

  1. Institut för Physiologie und Kardiologie, Waldstr. 6, D-8520, Erlangen, Germany

    Manfred Kessler , David Keith Harrison  & Jens Höper ,  & 

  2. Dept. of Chemistry, University of North Carolina, Chapel Hill, NC, 27514, USA

    R. P. Buck

  3. Dept. of Physiology, School of Medicine, The Center for Health Science, University of California, Los Angeles, California, 90024, USA

    G. Eisenman

  4. Biosensors Inc., PO Box 640, Chester, New Jersey, 07930, USA

    J. Hill

  5. Faculty of Medicine, American Univ. of Beirut, Beirut, Lebanon

    R. N. Khuri

  6. Direktor des Max-Planck-Instituts für Systemphysiologie, Rheinlanddamm 201, 4600, Dortmund 1, Germany

    D. W. Lübbers

  7. Medical Center, Dept. of Physiology and Biophysics, New York University, 550 First Avenue, New York, NY, 10016, USA

    C. Nicholson

  8. Laboratorium für Organische Chemie, Universitätsstr. 16, 6000, Frankfurt M. 70, Germany

    W. Simon

  9. The Middlesex Hospital, Mortimer St., London W N, 8AA, England

    T. Treasure

  10. Institute of Medical Physiology, Dept. A, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    T. Zeuthen

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© 1985 Springer-Verlag Berlin Heidelberg

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Glitsch, H.G., Pusch, H., Schumacher, T. (1985). Temperature Dependence of the Cardiac Na+ — K+ Pump as Studied by Na-Sensitive Microelectrodes. In: Kessler, M., et al. Ion Measurements in Physiology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70518-2_43

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  • DOI: https://doi.org/10.1007/978-3-642-70518-2_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15468-6

  • Online ISBN: 978-3-642-70518-2

  • eBook Packages: Springer Book Archive

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