Effect of Hypocalcemia on Neuromuscular Function in Cats

  • B. W. Allen
  • G. G. Somjen
  • D. B. Sanders


The neuromuscular disturbances caused by acute hypocalcemia have been recognized clinical entities for decades. However, we know of no data in the literature that relate specific clinical disorders to precise threshold levels of plasma calcium ion concentration. The relatively recent availability of ion-selective electrodes (1967 for calcium, [12]) permits study of the effects of calcium deficiency in intact animals and human patients. We are conducting a continuing series of experiments on the effects of altered plasma [Ca2+] in cats [1–4,14]. Here, we report the effect of acute hypocalcemia on neuromuscular function in vivo.


Compound Muscle Action Potential Neuromuscular Function Single Shock Compound Muscle Action Potential Amplitude Individual Muscle Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Allen BW (1981) Blood calcium activity and cardiac function (Abstr). Physiologist 24: 62Google Scholar
  2. 2.
    Allen BW, Somjen GG (1983) The influence of pH on [Ca2+] in circulating blood (Abstr). Fed Proc 42: 296Google Scholar
  3. 3.
    Allen BW, Possillico JT, Somjen GG (1982) Lowered blood calcium activity, neuromuscular function, and respiration (Abstr). Fed Proc 41:1734Google Scholar
  4. 4.
    Allen BW, Somjen GG, Sanders DB (1983) Muscle afterdischarge masks neuromuscular blockade in moderate hypocalcemia (Abstr). Soc Neurosci Abstr 9 (1): 11Google Scholar
  5. 5.
    De Keyzer J, van der Straeten G, van Es I (1982) Elektromyografische bevindingen bij spasmophilic. J Beige Med Phys Rehabil 4:195–200Google Scholar
  6. 6.
    Hansen AJ, Lund-Andersen H, Crone C (1977) K+-permeability of the blood-brain barrier investigated with the aid of a K+-sensitive microelectrode. Acta Physiol Scand 101: 438–445PubMedCrossRefGoogle Scholar
  7. 7.
    Jesserer H (1958) Tetanie. Thieme, StuttgartGoogle Scholar
  8. 8.
    Kuffler SW (1945) Excitability changes of the neuromuscular junction during tetany. J Physiol (Lond) 103:403–411Google Scholar
  9. 9.
    Kugelberg E (1948) Activation of human nerves by hyperventilation and hypocalcemia; neurologic mechanism of symptoms of irritation in tetany. Arch Neurol Psychiatry 60:153–164Google Scholar
  10. 10.
    Ridgeway EB, Gordon AM, Martyn DA (1983) Hysteresis in the force-calcium relation in muscle. Science 219:1075–1077CrossRefGoogle Scholar
  11. 11.
    Root AW, Harrison HE (1976) Recent advances in calcium metabolism. II. Disorders of calcium homeostasis. J Pediatr 88:177–199PubMedCrossRefGoogle Scholar
  12. 12.
    Ross JW (1967) Calcium-selective electrode with liquid ion exchanger. Science 156:1378–1379PubMedCrossRefGoogle Scholar
  13. 13.
    Simpson JA (1973) Neuromuscular diseases; Section VIII: Spontaneous activity and myotonic, tetanic and cramp syndromes. Handbook Electroencephalogy Clin Neurophysiol 16/B: 68–79Google Scholar
  14. 14.
    Somjen GG, Allen BW (1983) Does hyperventilation cause tetany? Proc Int Union Physiol Sci 15:146Google Scholar
  15. 15.
    Stalberg E, Trontelj J (1979) Single Fiber Electromyography. Mirvalle, Old Woking, Surrey, pp 3–8Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • B. W. Allen
  • G. G. Somjen
  • D. B. Sanders

There are no affiliations available

Personalised recommendations