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Effect of a Dihydropyridine-Type Calcium Antagonist on Cerebral Blood Flow and Metabolism

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Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 9))

Abstract

The calcium channel blocker, nimodipine, has been shown to have a preferential vasodilator action on the contraction of cerebrovascular smooth muscle induced by neurotransmitter and vasoconstrictor substances in vitro (Towart and Kazda 1982).

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References

  1. Brandt L, Andersson K-E, Edvinsson L, Ljunggren B (1981) Effects of extracellular calcium and of calcium antagonists on the contractile responses of isolated human pial and mesenteric arteries. J Cereb Blood Flow &Metabol 1:339–347.

    Article  CAS  Google Scholar 

  2. Harper AM (1966) Autoregulation of cerebral blood flow: influence of the arterial blood pressure on the blood flow through the cerebral cortex. J Neurol Neurosurg Psychiat 29:398–403.

    Article  PubMed  CAS  Google Scholar 

  3. Harper AM, Craigen L, Kazda S (1981) Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in primates. J Cereb Blood Flow & Metabol 1:349–356.

    Article  CAS  Google Scholar 

  4. Harper AM, McCulloch J (1985) Cerebral blood flow and cerebrovascular disease. In: Kennard, Swash (eds) Scientific basis of neurology. Churchill Livingstone, pp 518-532.

    Google Scholar 

  5. Mohammed AA, McCulloch J, Mendelow AD, Teasdale GM, Harper AM (1984) Effect of the calcium antagonist, nimodipine, on local cerebral blood flow: Relationship to arterial blood pressure. J Cereb Blood Flow & Metabol 4:206–211.

    Article  Google Scholar 

  6. Mohammed AA, Mendelow AD, Teasdale GM, Harper AM, McCulloch J (1985) Effect of the calcium antagonist, nimodipine, upon local cerebral blood flow and metabolic coupling. J Cereb Blood Flow & Metabol 5:26–33.

    Article  Google Scholar 

  7. Sakurada O, Kennedy C, Jehle J, Brown JD, Carbin GL, Sokoloff L (1978) Measurement of local cerebral blood flow with iodo [14C] antipyrine. Am J Physiol 234:H59–H66.

    PubMed  CAS  Google Scholar 

  8. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C]-deoxyglucose method for the measurement of local cerebral glucose utilization; theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897–916.

    Article  PubMed  CAS  Google Scholar 

  9. Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal cerebral ischaemia in the rat. 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow & Metabol 1:53–60.

    Article  CAS  Google Scholar 

  10. Towart R, Kazda S (1979) The cellular mechanism of action of nomodipine (Bay e 9736), a new calcium antagonist. Br J Pharmacol 67:409–410.

    Google Scholar 

  11. Towart R, Kazda S (1982) Preferential vasodilator actions of the calcium antagonists nimodipine (Bay e 9736), nifedipine and verapamil on contraction of cerebral vascular smooth muscles induced by neurotransmitter and vasoconstrictor substances. In: Heistad DD, Marcus ML (eds) Cerebral blood flow: Effect of nerves and neurotransmitters. Elsevier-North Holland, New York, pp 29–38.

    Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Harper, A.M. (1985). Effect of a Dihydropyridine-Type Calcium Antagonist on Cerebral Blood Flow and Metabolism. In: Fleckenstein, A., Van Breemen, C., Gross, R., Hoffmeister, F. (eds) Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists. Bayer-Symposium, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70499-4_22

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  • DOI: https://doi.org/10.1007/978-3-642-70499-4_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70501-4

  • Online ISBN: 978-3-642-70499-4

  • eBook Packages: Springer Book Archive

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