Anatomy and Physiology of the Chemoreceptor Trigger Zone and Area Postrema

  • H. L. Borison
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 3)

Abstract

It was not until the vomiting centre itself was correctly localized in the bulbar reticular formation that the idea of a separate chemosensory station could be formulated (Borison and Wang 1953). Figure 1 shows where the vomiting centre was thought to be located before 1949 (panel A) and then where it was mapped by Borison and Wang (1949) (panel B). Earlier workers (Hatcher and Weiss 1923) simply assumed that the vomiting centre was inherently responsive to “centrally-acting” emetic drugs applied locally to the ala cinerea on the brain surface; whereas, we used direct electrical stimulation to activate the centre in the parenchymal reticular formation. Indeed, there is at present no neuropharmacological basis for attributing any functional chemoselectivity to the particular medullary neurons that comprise the vomiting centre.

Keywords

Catheter Assure Angiotensin Glycoside Bori 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. L. Borison
    • 1
  1. 1.Department of Pharmacology and Toxicology, Institute of Brain Stem StudiesDartmouth Medical SchoolHanoverUSA

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