Abstract
The interaction of inorganic species with membranes can play a significant role in their biological effects. To the extent that membranes prevent the entry of these species into cells, they will inhibit damaging effects. However, many interactions with membranes can result in direct damage or, more seriously, can lead to an amplification of toxicity. Direct damage can include structural alteration such as a disruption of vital lipid-protein associations or introduction of new surface charges. More substantial damage can occur when inorganic species impair membrane function catalytically, e.g., by providing ion conductance pathways or by promoting freeradical reactions which may cause massive oxidation of membrane lipids. Recognition of factors involved in the interaction of compounds with membranes may be useful in devising meaningful strategies for the determination of inorganic species in biological environments.
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© 1986 Dr. S. Bernhard, Dahlem Konferenzen
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Mehlhorn, R.J. (1986). The Interaction of Inorganic Species with Biomembranes. In: Bernhard, M., Brinckman, F.E., Sadler, P.J. (eds) The Importance of Chemical “Speciation” in Environmental Processes. Dahlem Workshop Reports, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70441-3_7
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DOI: https://doi.org/10.1007/978-3-642-70441-3_7
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