The Tilt Formula for CNS Lesions: Effects of Dimethyl Sulfoxide
There are presently no criteria to grade CNS lesions for the purpose of assessing the value of an experimental or clinical therapy. We have devised a simple formula to score CNS injuries that allows evaluation of the strength of a given treatment. The formula is based on 4 descriptive parameters which characterize the lesion. These factors are: type of lesion, intensity, location and time of duration (TILT). When each parameter in TILT is graded, a collective score can be expressed which results in an index of therapeutic efficacy with respect to a given treatment as applied to the CNS lesion (Traumindex). For the purpose of analysis, we have chosen to evaluate the therapeutic index of dimethyl sulfoxide (DMSO) because a number of studies have reported using this drug for a wide range of CNS lesions in both experimental and clinical subjects (s. References).
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