Abstract
Epidermal growth factor (EGF), first described by Cohen [2], may be an important endogenous mediator of the control of growth and differentiation of skin [1, 4]. As determined by 125I-EGF autoradiography, EGF receptors are localised in skin to cells which have growth potential [6]. In addition, evidence which suggests that there is a close relationship between mitotic rate and EGF receptor density in epidermal basal cells of the neonatal rat has been described by Green et al. [6]. The results presented here demonstrate that concomitantly with the epidermal hyperplasia induced by a chemical stimulus, EGF receptor density is dramatically reduced. An almost total disappearance of EGF receptor sites occurs some 24 h after a sufficient hyperplastic stimulus. Following a period of similar duration, the EGF receptor complement is restored to normal.
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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Basketter, D.A. (1986). Modulation of EGF Receptors during Epidermal Hyperplasia. In: Marks, R., Plewig, G. (eds) Skin Models. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70387-4_23
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DOI: https://doi.org/10.1007/978-3-642-70387-4_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70389-8
Online ISBN: 978-3-642-70387-4
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