Experimental Contact Dermatitis Using 2,4-Dinitrochlorobenzene in Humans
Contact dermatitis, due to both allergenic (sensitising) and irritant (non-sensitising) agents is a major clinical problem in industry and the home. Although its prevalence in a population depends on the nature of employment and industry, and environmental factors, it has been shown that one type of contact dermatitis alone, hand eczema, affects 2% of men and 3% of women . Industrial dermatitis in fact accounts for about 65% of all spells of absence from work in the United Kingdom recorded under prescribed diseases .
KeywordsContact Dermatitis Alopecia Areata Bronchogenic Carcinoma Cutaneous Contact Contact Allergic Reaction
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- 1.Agrup G (1969) Hand eczema and other hand dermatoses in Sweden. Acta Derm Venereol (Stockh) 49: 1–91Google Scholar
- 4.Buckner D, Price NM (1978) Immunotherapy of verrucae vulgares with dinitrochlorobenzene. Br. J Dermatol 98: 451–454Google Scholar
- 6.Catalona WB, Taylor P, Rabson A, Chretien P (1972) A method for dinitrochlorobenzene contact sensitization. A clinico-pathological study. New Engl J Med 286: 399Google Scholar
- 9.Office of Health Economics (1973) Skin Disorders O.H. E. Publication No 46: 10Google Scholar
- 10.Polak L (1980) Monographs in Allergy, vol 15. Immunological Aspects of Contact Sensitivity. KargerGoogle Scholar
- 11.Silberberg I (1973) Apposition of mononuclear cells to Langerhans cells in contact allergic reactions. An ultrastructural study. Acta Derm Venerol (Stockh) 53: 1–12Google Scholar
- 12.Silberberg-Sinakin I, Thorbecke GJ (1980) Contact hypersensitivity and Langerhans cells. Acta Derm Venerol (Stockh) 75: 61–67Google Scholar
- 13.Strauss GH, Bridges BA, Greaves M, Hall-Smith P, Price M, Vella-Briffa D (1980) Inhibition of delayed hypersensitivity reaction in skin (DNCB) test by 8-methoxypsoralen photochemotherapy. Lancet ii: 556Google Scholar
- 14.Weisburger EK, Russfield AB, Hamburger F, Weisburger JH, Boger E, Van Dougen CG, Chu KC (1978) Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity. J Environ Path Tox 2: 325–356Google Scholar