Self-Renewal of Haemopoietic Stem Cells: The Roles of the Environment, of Growth Factors and of the src Oncogene

  • T. M. Dexter
  • D. Boettiger
  • E. Spooncer
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)


Haemopoietic stem cells are derived early in embryogenesis, are relatively few in number, but persist throughout adult life by virtue of their ability to undergo self-renewal. This ability to undergo self-renewal is a characteristic and essential property of stem cells: in the absence of self-renewal the haemopoietic system would rapidly decline, while excessive and persistent self-renewal (in the absence of death or differentiation) would lead to a dramatic reduction in the production of mature cells and an increase in primitive cells, i. e. a leukaemia [24, 35]. It follows, then, that an investigation of self-renewal and differentiation is an over-riding problem in the understanding of growth control in normal tissues as well as the lack of growth control which occurs during tumourigenesis. In this context, the role of tissue and cell lineage-restricted growth factors and of oncogenes (and their produets) is assuming more and more importance [16, 48]. In this communication, the role of one such growth factor (haemopoietic cell growth factor), the stromal cell milieu, and the src oncogene are discussed in relation to self-renewal and differentiation of haemopoietic cells.


Haemopoietic Stem Cell Haemopoietic Cell Murine Mast Cell Mast Cell Growth Factor Haemopoietic System 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • T. M. Dexter
    • 1
  • D. Boettiger
    • 2
  • E. Spooncer
    • 1
  1. 1.Department of Experimental Haematology, Paterson LaboratoriesChristie Hospital & Holt Radium InstituteWithington, ManchesterEngland
  2. 2.Department of MicrobiologyUniversity of PennsylvaniaUSA

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