Monoclonal Antibodies and Immunotoxins in Bone Marrow Transplantation: Purging Marrow of ALL or GVHD Cells with Preservation of Stem Cells

  • J. H. Kersey
  • D. Vallera
  • N. Ramsay
  • A. Filipovich
  • R. Youle
  • D. Neville
  • R. Stong
  • T. LeBien
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)

Abstract

Bone marrow transplantation is now in frequent use for the treatment of a number of hematologic diseases, including severe immune deficiencies, aplastic anemias, and acute and chronic leukemias. In allogeneic transplantation, a problem remains with graft versus host disease-producing immunocompetent cells which contaminate the marrow. In autologous transplantation for treatment of the leukemias, residual leukemic cells may result in the return of unwanted cells to the recipient. Thus, an objective for both autologous and allogeneic marrow transplantation has become the removal of these unwanted cells prior to infusion into the recipient.

Keywords

Toxicity Leukemia Anemia Cyclophosphamide Lactose 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. H. Kersey
  • D. Vallera
  • N. Ramsay
  • A. Filipovich
  • R. Youle
  • D. Neville
  • R. Stong
  • T. LeBien

There are no affiliations available

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