Abstract
Interest in helper and suppressor epitopes has been growing rapidly. It is now generally accepted that most antigens present structures (epitopes) to the immune system which are recognized preferentially by different sets of lymphocytes, as shown in Fig. 1. These sets belong to the effector compartment containing B cells, Tc cells (cytotoxic cells), and delayed-type hypersensitivity-mediating T cells (not shown), or to the regulatory compartment containing Th and Ts cells (helper and suppressors). Structures preferentially recognized by Th cells are termed helper epitopes, and so on, and the balance of the two types of regulatory epitope is known to be an important factor in determining the outcome of at least some immune responses. The presence of even a Single suppressor epitope may be enough to prevent a response from occurring.
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Mitchison, N.A. (1985). Repertoire Purging by Medium Concentration Self-Macromolecules is the Major Factor Determining Helper and Suppressor Repertoire Differences. In: Neth, R., Gallo, R.C., Greaves, M.F., Janka, G. (eds) Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70385-0_2
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DOI: https://doi.org/10.1007/978-3-642-70385-0_2
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