Abstract
While B lymphocytes can bind antigen directly, T lymphocytes recognize antigen only when presented together with major histocompatibility complex (MHC)-en-coded class I or II molecules in the membrane of antigen-presenting cells (APC). This is called MHC restriction and was first shown in animal studies (see [5, 25] for references). The parts of the MHC molecule which are co-recognized together with antigen are often called restriction elements.
Work supported by grants from the Norwegian Cancer Society, The Norwegian Diabetes Society, and the University of Oslo
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Qvigstad, E., Bruserud, Ø., Thorsby, E. (1986). The Role of Human Class II Molecules in Activation of T4 Lymphocytes. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_28
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DOI: https://doi.org/10.1007/978-3-642-70367-6_28
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