Expression of Class II Antigens on Nonhematopoietic Tumor Cells

  • S. Carrel
  • J.-P. Mach
  • P. Ferremi
  • L. Giuffré
  • R. S. Accolla

Abstract

Class II antigens constitute a heterogeneous and polymorphic family of molecules encoded in the major histocompatibility complex (MHC) and primarily expressed on B cells, macrophages, and activated T cells [1]. However, not only lymphoid cells and macrophages express class II antigens. Hammerling et al. [2] first reported that murine epidermal cells and epididymal sperm cells expressed Ia determinants.

Keywords

Leukemia Adenocarcinoma Electrophoresis Interferon Neurol 

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References

  1. 1.
    Accolla RS, Moretta A, Mach JP (1984) The human Ia system: an overview. Semin Hematol 21:287–301PubMedGoogle Scholar
  2. 2.
    Hämmerling GJ, Mauve G, Goldberg E, McDevitt HO (1975) Tissue distribution of Ia antigens: Ia on spermatozoa, macrophages, and epidermal cells. Immunogenetics 1:428–437CrossRefGoogle Scholar
  3. 3.
    Rowden G, Lewis MG, Sullivan AK (1977) Ia antigen expression on human epidermal Langerhans cells. Nature 268:247–248PubMedCrossRefGoogle Scholar
  4. 4.
    Klarkeskog L, Tjernlund UM, Forsum U, Peterson PA (1977) Epidermal Langerhans cells express Ia antigens. Nature 268:248–250CrossRefGoogle Scholar
  5. 5.
    Stingl G, Katz SI, Abelson LA, Mann DL (1978) Immunofluorescent detection of human B cell alloantigens on s-Ig-positive lymphocytes and epidermal Langerhans cells. J Immunol 120:661–664PubMedGoogle Scholar
  6. 6.
    Haines KA, Flotte TJ, Springer TA, Gigli I, Thonbecke GJ (1983) Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells. Proc Natl Acad Sci USA 80:3448–3451PubMedCrossRefGoogle Scholar
  7. 7.
    Winchester RJ, Wang C, Gibofsky A, Kunkel HG, Lloyd KO, Old LJ (1978) Expression of Ia-like antigens on cultured human malignant melanoma cell lines. Proc Natl Acad Sci USA 75:6235–6239PubMedCrossRefGoogle Scholar
  8. 8.
    Wilson BS, Indiven F, Pellegrino MA, Ferrone S (1979) DR (Ia-like) antigens on human melanoma cells. Serological detection and immunochemical characterization. J Exp Med 149:658–668PubMedCrossRefGoogle Scholar
  9. 9.
    Natali PG, de Martino C, Quaranta V, Bigotti A, Pellegrino MA, Ferrone S (1981) Changes in Ia-like antigen expression on malignant human cells. Immunogenetics 12:409–413PubMedCrossRefGoogle Scholar
  10. 10.
    Lloyd KO, Ng J, Dippold WH (1981) Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines. J Immunol 126:2408–2413PubMedGoogle Scholar
  11. 11.
    Mitchell KF, Ward FE, Koprowski H (1982) DR antigens on melanoma cells: analysis with monoclonal antibodies. Human Immunol 4:15–26CrossRefGoogle Scholar
  12. 12.
    Thompson JJ, Herlyn MF, Elder DE, Clark WH, Steplewski Z, Koprowski H (1982) Expression of DR antigens in freshly frozen human tumors. Hybridoma 1:161–168PubMedCrossRefGoogle Scholar
  13. 13.
    Carrel S, Gross N, Heumann D, Mach JP (1979) Expression of “Ia-like” antigens on cells from a human endometrial carcinoma cell line END-1. Transplantation 27:431–433PubMedGoogle Scholar
  14. 14.
    Carrel S, Tosi R, Gross N, Tanigaki N, Carmagnola AL, Accolla RS (1981) Subsets of human Ia-like molecules defined by monoclonal antibodies. Mol Immunol 18:403–411PubMedCrossRefGoogle Scholar
  15. 15.
    Pollack MS, Heagney SD, Livingston PO, Fogh J (1981) HLA-A,B,C and DR alloan-tigen expression of forty-six cultured human tumor cell lines. J Natl Cancer Inst 66:1003–1012PubMedGoogle Scholar
  16. 16.
    MacLean GD, Seehafer J, Shaw ARE, Kieran MW, Longenecker BM (1982) Antigenic heterogeneity of human colorectal cancer cell lines analyzed by a panel of monoclonal antibodies I. Heterogeneous expression of Ia-like and HIa-like antigenic determinants. J Natl Cancer Inst 69:357–364PubMedGoogle Scholar
  17. 17.
    Guesdon JL, Ternynck T, Avrameas S (1979) The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem 27:1131–1139PubMedCrossRefGoogle Scholar
  18. 18.
    Carrel S, Schreyer M, Schmidt-Kessen A, Mach JP (1982) Reactivity spectrum of 30 monoclonal antimelanoma antibodies to a panel of 28 melanoma and control cell lines. Hybridoma 1:387–397PubMedCrossRefGoogle Scholar
  19. 19.
    Poste G, Doll J, Fidler J (1981) Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci USA 78:6226–6230PubMedCrossRefGoogle Scholar
  20. 20.
    Daar AS, Fuggle SV, Ting A, Fabre JW (1982) Anomolous expression of HLA-DR antigens on human colorectal cancer cells. J Immunol 129:447–449PubMedGoogle Scholar
  21. 21.
    Natali PG, Giacomini P, Bigotti A, Imai K, Nicotra MR, Ng AK, Ferrone S (1983) Heterogeneity in the expression of HLA and tumor-associated antigens by surgically removed and cultured breast carcinoma cells. Cancer Res 43:660–668PubMedGoogle Scholar
  22. 22.
    de Tribolet N, Carrel S, Mach JP (1984) Brain-tumor-associated antigens. Prog Exp Tumor Res 27:118–131PubMedGoogle Scholar
  23. 23.
    de Tribolet N, Hamou MF, Mach JP, Carrel S, Schreyer M (1984) Demonstration of HLA-DR antigens in normal human brain. J Neurol Neurosurg Psychiatry 47:417–418PubMedCrossRefGoogle Scholar
  24. 24.
    Berle EJ, Braathen LR, Throsby E (1982) HLA-D/DR restriction of Langerhans cell-dependent antigen activation of T lymphocytes. Scand J Immunol 16:549–552PubMedCrossRefGoogle Scholar
  25. 25.
    Pollack MS, Goldenhersh M, Chin-Louie J, Safai B (1982) The functional study of DR-positive human epidermal Langerhans cells in mixed cell cultures with allogeneic lymphocytes. Clin Immunol Immunopathol 24:12–25CrossRefGoogle Scholar
  26. 26.
    Howe AJ, Seeger RC, Molinaro GA, Ferrone S (1981) Analysis of human tumor cells for Ia-like antigens with monoclonal antibodies. J Natl Cancer Inst 60:827–829Google Scholar
  27. 27.
    Lloyd KO, Ng J, Dippold WG (1981) Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines. J Immunol 126:2408–2413PubMedGoogle Scholar
  28. 28.
    Natali PG, Bigotti A, Nicotra MR, Viora M, Manfredi D, Ferrone S (1984) Distribution of human class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin. Cancer Res 44:4679–4687PubMedGoogle Scholar
  29. 29.
    Ruiter DJ, Bergman K, Welvaart K, Scheffer E, von Vloten WA, Russo C, Ferrone S (1984) Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens. Cancer Res 44:3930–3935PubMedGoogle Scholar
  30. 30.
    Pollack MS, Heagney SD, Livingston PO, Fogh J (1981) HLA-A,B,C and DR alloan-tigen expression of forty-six cultured human tumor cell lines. J Natl Cancer Inst 66:1003–1012PubMedGoogle Scholar
  31. 31.
    Carrel S, de Tribolet N, Gross N (1982) expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells. Eur J Immunol 12:354–357PubMedCrossRefGoogle Scholar
  32. 32.
    Daar AS, Fabre JW (1983) The membrane antigens of human colorectal cancer cells: demonstration with monoclonal antibodies of heterogeneity within and between tumors and anomalous expression of HLA-DR. Eur J Cancer Clin Oncol 19:209–220PubMedCrossRefGoogle Scholar
  33. 33.
    Shackelford DA, Strominger JL (1983) Analysis of the oligosaccharides on the HLA-DR and DC1 B cell antigens. J Immunol 130:274PubMedGoogle Scholar
  34. 34.
    Tosi R, Tanigaki N, Centis D, Ferrara GB, Pressman D (1978) Immunological dissection of human Ia molecules. J Exp Med 148:1592–1611PubMedCrossRefGoogle Scholar
  35. 35.
    Corte G, Damiani G, Calabi F, Fabbi M, Bargellesi A (1981) Analysis of HLA-DR polymorphism by two-dimensional peptide mapping. Proc Natl Acad Sci USA 78:534–558PubMedCrossRefGoogle Scholar
  36. 36.
    Accolla RS, Gross N, Carrel S, Corte G (1981) Distinct forms of both α and β subunits are present in the human Ia molecular pool. Proc Natl Acad Sci USA 78:4549–4551PubMedCrossRefGoogle Scholar
  37. 37.
    Accolla RS (1983) Analysis of the structural heterogeneity and polymorphism of human Ia antigens. J Exp Med 159:378–393CrossRefGoogle Scholar
  38. 38.
    Wake CT, Long EO, Strubin M, Gross N, Accolla RS, Carrel S, Mach B (1982) Isolation of c-DNA clones encoding HLA-DR chains. Proc Natl Acad Sci USA 79:6979–6983PubMedCrossRefGoogle Scholar
  39. 39.
    Alexander S, Hubbard SC, Strominger JL (1984) HLA-DR antigens of autologous melanoma and B lymphoblastoid cell lines: differences in glycosylation but not protein structure. J Immunol 133:315–320PubMedGoogle Scholar
  40. 40.
    Cillo C, Mach JP, Schreyer M, Carrel S (1984) Antigenic heterogeneity of clones and subclones from human melanoma cell lines demonstrated by a panel of monoclonal antibodies and flow microfluorometry analysis. Int J Cancer 34:11–20PubMedCrossRefGoogle Scholar
  41. 41.
    Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38:2651–2660PubMedGoogle Scholar
  42. 42.
    Fidler IJ, Hart IR (1982) Biological diversity in metastatic neoplasms: origins and implication. Science 217:998–1003PubMedCrossRefGoogle Scholar
  43. 43.
    Woodruff MFA (1983) Cellular heterogeneity in tumors. Br J Cancer 47:589–594PubMedCrossRefGoogle Scholar
  44. 44.
    Nicolson GL (1984) Cell surface molecules and tumor metastasis. Exp Cell Research 150:3–22CrossRefGoogle Scholar
  45. 45.
    Lindahl P, Leary P, Gresser I (1972) Enhancement by interferon of the expression of surface antigens on murine leukemia LI210 cells. Proc Natl Acad Sci USA 69:721–723PubMedCrossRefGoogle Scholar
  46. 46.
    Heron I, Hokland M, Berg K (1978) Enhanced expression of B2-microglobulin and HLA antigens on human lymphoid cells by interferon. Proc Natl Acad Sci USA 75:6215–6219PubMedCrossRefGoogle Scholar
  47. 47.
    Fellous M, Kamoun M, Gresser I, Bono R (1979) Enhanced expression of HLA antigens and beta 2 microglobulin on interferon-treated human lymphoid cells. Eur J Immunol 9:446–449PubMedCrossRefGoogle Scholar
  48. 48.
    Kelley VE, Fiers W, Strom TB (1984) Cloned human interferon–γ but not interferon–α or β induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines. J Immunol 132:240–245PubMedGoogle Scholar
  49. 49.
    Imai K, Ng AK, Glassy MC, Ferrone S (1981) Differential effect of interferon on the expression of tumor-associated antigens and histocompatibility antigens on human melanoma cells: relationship to susceptibility to immune lysis mediated by monoclonal antibodies. J Immunol 127:505–508PubMedGoogle Scholar
  50. 50.
    Liao SK, Kurong PC, Khosravi M, Dent PB (1982) Enhanced expression of melanoma-associated antigens and B2-microglobulin on cultured human melanoma cells by interferons. J Natl Cancer Inst 68:19–25PubMedGoogle Scholar
  51. 51.
    Basham TY, Merigan TC (1983) Recombinant interferon–γ increases HLA-DR synthesis and expression. J Immunol 130:1492–1494PubMedGoogle Scholar
  52. 52.
    Ziegler A, Uchaneka-Ziegler B, Rosenfelder G, Braun DG, Wernet P (1981) Heterogeneity of established human hematopoietic cell lines: surface antigens detected by monoclonal antibodies and glycosphingolipid patterns. In: Leukemia markers. Knapp, Diisseldorf, pp 317–320Google Scholar
  53. 53.
    Carrel S, Schmidt-Kessen A, Giuffré L (1985) Recombinant interferon–γ can induce the expression of HLA-DR and –DC on DR-negative melanoma cells and enhance the expression of HLA-ABC and tumor associated antigens. Eur J Immunol 15:118–123PubMedCrossRefGoogle Scholar
  54. 54.
    Houghton AN, Thomson TM, Gross D, Oettgen HF, Old LJ (1984) Surface antigens of melanomas and melanocytes. Specificity of induction of Ia antigens by human γ–in-terferon. J Exp Med 160:255–269PubMedCrossRefGoogle Scholar
  55. 55.
    Nakamura M, Mauser T, Pearson GPN, Daley MJ, Geffer ML (1984) Effect of IFN–γ on the immune response in vivo and on gene expression in vitro. Nature 307:381–382PubMedCrossRefGoogle Scholar
  56. 56.
    Rosa F, Hatat D, Abadie A, Wallach D, Revel M, Fellous M (1983) Differential regulation of HLA-DR mRNAs and cell surface antigens by interferon. EMBO J 2:1585–1589PubMedGoogle Scholar
  57. 57.
    Reitz MS, Mann DL, Eiden M, Trainor CD, Clarke MF (1984) DNA methylation and expression of HLA-DR. Mol Cell Biol 4:890–897PubMedGoogle Scholar
  58. 58.
    Pollack MS (1981) The detection of weak allogeneic stimulation by DR-positive cell lines. Transplant Proc 13:1947–1951PubMedGoogle Scholar
  59. 59.
    Du Pont Guerry IV D, Zehngebot LM, Mitchel KF, Zmijewski CM, Lask EJ (1984) HLA-DR histocompatibility leukocyte antigens permit cultured human melanoma cells from early but not advanced disease to stimulate autologous lymphocytes. J Clin Invest 73:267–271CrossRefGoogle Scholar
  60. 60.
    Zehngebot LM, Alexander MA, Guerry IV D, Cines DB, Mitchell K, Herlyn M (1983) Functional consequence of variation in melanoma antigen expression. Cancer Immunol Immunother 16:30–34PubMedCrossRefGoogle Scholar
  61. 61.
    Fossati G, Taramelli D, Balsari A, Bogdanovich G, Andreola S, Parmiani G (1984) Primary but not metastatic human melanomas expressing DR antigens stimulate autologous lymphocytes. Int J Cancer 33:591–597PubMedCrossRefGoogle Scholar
  62. 62.
    Knuth A, Danowski B, Oettgen HF, Old LJ (1984) T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin-2-dependent T-cell cultures. Proc Natl Acad Sci USA 81:3511–3515PubMedCrossRefGoogle Scholar
  63. 63.
    de Vries JE, Spits H (1984) Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phe-notype and specificity. J Immunol 132:510–519PubMedGoogle Scholar
  64. 64.
    Accolla R S(1983) Human BNcell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets. J Exp Med 157:1053–1058PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Carrel
  • J.-P. Mach
  • P. Ferremi
  • L. Giuffré
  • R. S. Accolla

There are no affiliations available

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