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Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects

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HLA Class II Antigens

Abstract

When the immune system is activated, complex cell-cell interactions are initiated which ultimately lead to one or more of several well-known kinds of response. The quality and extent of these responses depend largely upon the particular subset of immune cells which are activated and the balance between the various subsets of activated and other cells involved. The cells which participate in the immune response interact through MHC and other cell membrane molecules. An important consequence of activation is the appearance of molecules on the cell surface which are not normally detectable on resting cells. T cells, for example, when activated, undergo profound changes such as increases in RNA, DNA and rate of protein synthesis, accompanied by the appearance of large nucleoli and abundant euchromatin and a vast increase in the amount of endoplasmic reticulum. These processes culminate in phenotypic variations, including changes in the MHC antigenic profile.

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Authors
  1. H. Festenstein
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  2. L. Fainboim
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  3. D. Jaraquemada
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  4. C. Navarrete
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Editor information

Editors and Affiliations

  1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Pilestredet 32, N-0027, Oslo 1, Norway

    Bjarte G. Solheim (Director) (Director)

  2. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, S-14186, Huddinge, Sweden

    Erna Møller

  3. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY, 10595, USA

    Soldano Ferrone

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© 1986 Springer-Verlag Berlin Heidelberg

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Festenstein, H., Fainboim, L., Jaraquemada, D., Navarrete, C. (1986). Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-70367-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70369-0

  • Online ISBN: 978-3-642-70367-6

  • eBook Packages: Springer Book Archive

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