Genes and Antigens of the HLA-D Region

  • P. A. Peterson
  • L. Rask


The role of the major histocompatibility complex (MHC) in rejections of transplanted organs was recognized early. The combined efforts of immunologists and immunogeneticists demonstrated that the human MHC represents one of the most genetically polymorphic loci hitherto identified. The genetic polymorphism as such may have represented the greatest immunological obstacle to successful transplantations. However, it was soon realized that a surprisingly large number of cells of the immune system are committed to recognizing the products of the MHC. This made it clear that MHC molecules also have central roles in physiological immune responses. Thus, the obsession of the immune system with these polymorphic proteins sets them apart from other endogeneous molecules in initiating a graft rejection.


Major Histocompatibility Complex Cytoplasmic Tail Invariant Chain Major Histocompatibility Complex Antigen Antigen Polymorphism 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • P. A. Peterson
  • L. Rask

There are no affiliations available

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