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The Role of the Cell Surface Components of Pseudomonas aeruginosa in Virulence

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The Pathogenesis of Bacterial Infections

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 8))

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Summary

A variety of roles in virulence, both direct and indirect, can be ascribed to the outer membrane components of Pseudomonas aeruginosa. These include the endotoxic nature of Pseudomonas lipopolysaccharide (LPS) owing to a lipid A region which cross-reacts antigenically with other gram-negative lipid As. In addition, LPS composition has a direct influence on serum susceptibility of P. aeruginosa. A variety of outer membrane proteins are mitogenic for murine B lymphocytes and immunogenic in both animals and humans. Presumably, these properties could be involved in modulation of virulence. A major role in the virulence of P. aeruginosa in antibiotic-treated humans is afforded by the low outer membrane permeability and consequent intrinsic antibiotic resistance of this organism. Some of these properties have now been manipulated to provide new methods of anti-pseudomonal therapy.

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Authors
  1. R. E. W. Hancock
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Editors and Affiliations

  1. Department of Medicine, Section of Infectious Diseases, The University of Illinois at Chicago College of Medicine, Box 6998, 60680, Chicago, IL, USA

    George Gee Jackson

  2. Bayer AG, Pharma-Forschungszentrum, Institut für Chemotherapie, Postfach 101709, D-5600, Wuppertal 1, Germany

    Herbert Thomas

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© 1985 Springer-Verlag Berlin Heidelberg

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Hancock, R.E.W. (1985). The Role of the Cell Surface Components of Pseudomonas aeruginosa in Virulence. In: Jackson, G.G., Thomas, H. (eds) The Pathogenesis of Bacterial Infections. Bayer-Symposium, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70351-5_21

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  • DOI: https://doi.org/10.1007/978-3-642-70351-5_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70353-9

  • Online ISBN: 978-3-642-70351-5

  • eBook Packages: Springer Book Archive

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