Abstract
Knowledge of how coupling affects the collective behavior of aggregates of more or less identical cells or dynamical systems is important for understanding both normal and aberrant processes in numerous physical and biological systems. These include pattern-formation in developmental biology, the spatial and temporal coordination of cellular activity in the heart and the nervous system, spatial and temporal pattern-formation in chemically-reacting systems, and many more. In some instances, the aberrant behavior of the system is directly attributable to alterations in intercellular communication. For example, epileptic seizures consist of uncontrolled synchronized discharges in the central nervous system, and epileptogenic drugs that cause the rapid depolarization of neurons characteristic of the onset of a seizure act on chemical [1,2] or electrical synapses [3], thereby altering the type or intensity of communication between neurons. At a more accessible level, coupled electrical circuits can be used as model systems to demonstrate the dramatic effect that changes in coupling can have [4].
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Othmer, H.G. (1985). Synchronization, Phase-Locking and Other Phenomena in Coupled Cells. In: Rensing, L., Jaeger, N.I. (eds) Temporal Order. Springer Series in Synergetics, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70332-4_19
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DOI: https://doi.org/10.1007/978-3-642-70332-4_19
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